OBJECTIVES: To examine the effect of burden of treatment and multimorbidity on the relationship between baseline characteristics and oral oncolytic agent (OOA) temporary stoppages. SAMPLE & SETTING:272 patients newly prescribed OOAs at six National Cancer Institute-designated comprehensive cancer centers. METHODS & VARIABLES: Patients were randomly assigned to an adherence and symptom management group or a usual care/control group. Temporary OOA stoppages, symptom interference, OOA regimen complexity, and multimorbidities were explored. Data were collected at four-week intervals for 12 weeks. RESULTS: Burden of treatment variables and multimorbidity had no significant effect on OOA temporary stoppages. Women and those prescribed kinase inhibitors were significantly more likely to experience a temporary stoppage. IMPLICATIONS FOR NURSING: Oncology nurses are in a crucial position to educate patients on self-management of OOAs and symptoms. Nurses should be aware of patients who may be more susceptible to severe symptoms, including those with multimorbidities. Future research is needed to better understand OOA stoppages and factors associated with preventing stoppages.
RCT Entities:
OBJECTIVES: To examine the effect of burden of treatment and multimorbidity on the relationship between baseline characteristics and oral oncolytic agent (OOA) temporary stoppages. SAMPLE & SETTING: 272 patients newly prescribed OOAs at six National Cancer Institute-designated comprehensive cancer centers. METHODS & VARIABLES: Patients were randomly assigned to an adherence and symptom management group or a usual care/control group. Temporary OOA stoppages, symptom interference, OOA regimen complexity, and multimorbidities were explored. Data were collected at four-week intervals for 12 weeks. RESULTS: Burden of treatment variables and multimorbidity had no significant effect on OOA temporary stoppages. Women and those prescribed kinase inhibitors were significantly more likely to experience a temporary stoppage. IMPLICATIONS FOR NURSING: Oncology nurses are in a crucial position to educate patients on self-management of OOAs and symptoms. Nurses should be aware of patients who may be more susceptible to severe symptoms, including those with multimorbidities. Future research is needed to better understand OOA stoppages and factors associated with preventing stoppages.
Authors: Peter C Lo; Suzanne E Dahlberg; Mizuki Nishino; Bruce E Johnson; Lecia V Sequist; David M Jackman; Pasi A Jänne; Geoffrey R Oxnard Journal: Cancer Date: 2015-04-15 Impact factor: 6.860
Authors: Alla Sikorskii; Charles W Given; Barbara A Given; Eric Vachon; Victoria Marshall; John C Krauss; Asish Banik; Atreyee Majumder Journal: Psychooncology Date: 2018-01-11 Impact factor: 3.894
Authors: Gregory S Sawicki; Clement L Ren; Michael W Konstan; Stefanie J Millar; David J Pasta; Alexandra L Quittner Journal: J Cyst Fibros Date: 2013-01-24 Impact factor: 5.482
Authors: Viet-Thi Tran; Victor M Montori; David T Eton; Dan Baruch; Bruno Falissard; Philippe Ravaud Journal: BMC Med Date: 2012-07-04 Impact factor: 8.775
Authors: Jennifer L Ridgeway; Jason S Egginton; Kristina Tiedje; Mark Linzer; Deborah Boehm; Sara Poplau; Djenane Ramalho de Oliveira; Laura Odell; Victor M Montori; David T Eton Journal: Patient Prefer Adherence Date: 2014-03-19 Impact factor: 2.711
Authors: Marco Di Nitto; Fabio Sollazzo; Valentina Biagioli; Gianluca Pucciarelli; Francesco Torino; Rosaria Alvaro; Ercole Vellone Journal: Support Care Cancer Date: 2022-05-31 Impact factor: 3.359