Novel sample preparation approaches in gas chromatographic analysis: Promising ideas.

The development of sample preparation procedures is still a dynamic process despite a number of already proposed techniques. The main challenge in this research field is to fully replace classical procedures like liquid-liquid extraction and solid-phase extraction in gas chromatographic analysis. Some progress has been already achieved for the last 20 years when miniaturized techniques were incorporated in ISO standards. The current review is focused on novel approaches in sample treatment that appeared since 2010. It includes research studies describing non-conventional instrumental design available to inspire future progress in the field. A combination of a few extraction principles and supporting with additional treatment are the main core suggested for improvement of sample preparation efficiency. This requires good compatibility of extraction media, assessment of multiple experimental parameters, and potential automatization possibilities.