Literature DB >> 31422894

Striving Towards the Perfect In Vitro Oral Drug Absorption Model.

John P Gleeson1, Fiona McCartney2.   

Abstract

Oral drug delivery systems have multiple goals, assessing and enabling intestinal absorption at efficacious doses being one of them. Here we highlight the in vitro advances in modeling drug absorption, which more faithfully reflect human intestinal physiology and reduce the reliance on animal models.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Caco-2; drug absorption; intestinal organoids; in vitro-in vivo correlation; oral drug delivery

Mesh：

Substances：

Year:  2019        PMID： 31422894     DOI： 10.1016/j.tips.2019.07.010

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  4 in total

1.  The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology.

Authors:  John P Gleeson; Katherine C Fein; Namit Chaudhary; Rose Doerfler; Alexandra N Newby; Kathryn A Whitehead
Journal:  Int J Pharm       Date:  2020-11-26       Impact factor: 5.875

2.  Resistivity Technique for the Evaluation of the Integrity of Buccal and Esophageal Epithelium Mucosa for In Vitro Permeation Studies: Swine Buccal and Esophageal Mucosa Barrier Models.

Authors:  Jaiza Samara Macena de Araújo; Maria Cristina Volpato; Bruno Vilela Muniz; Gabriela Gama Augusto Xavier; Claudia Cristina Maia Martinelli; Renata Fonseca Vianna Lopez; Francisco Carlos Groppo; Michelle Franz-Montan
Journal:  Pharmaceutics       Date:  2021-04-30       Impact factor: 6.321

3.  Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging.

Authors:  Arjen Weller; Morten B Hansen; Rodolphe Marie; Adam C Hundahl; Casper Hempel; Paul J Kempen; Henrik L Frandsen; Ladan Parhamifar; Jannik B Larsen; Thomas L Andresen
Journal:  Front Bioeng Biotechnol       Date:  2022-09-09

4.  Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat.

Authors:  Patrik Lundquist; Georgiy Khodus; Zhigao Niu; Lungile Nomcebo Thwala; Fiona McCartney; Ivailo Simoff; Ellen Andersson; Ana Beloqui; Aloise Mabondzo; Sandra Robla; Dominic-Luc Webb; Per M Hellström; Åsa V Keita; Eduardo Sima; Noemi Csaba; Magnus Sundbom; Veronique Preat; David J Brayden; Maria Jose Alonso; Per Artursson
Journal:  ACS Nano       Date:  2022-08-23       Impact factor: 18.027
  4 in total

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