Takahiro Ushida1, Daiju Matsui2, Teruyoshi Inoue2, Mizuka Yokoyama2, Hiroshi Takatsuna2, Takuyuki Matsumoto3, Atsushi Takita4, Takao Kurusu5, Hiroshi Sakoda2, Kaoru Okuizumi2. 1. Multidisciplinary Pain Center, Aichi Medical University , Aichi , Japan. 2. Medical Affairs Division, Medical Science Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan. 3. Quality & Safety Management Division, Safety and Risk Management Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan. 4. R&D Division, Biostatistics & Data Management Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan. 5. Rx Group, Data Solution Division, Japan Medical Information Research Institute, Inc ., Tokyo , Japan.
Abstract
Background: Information on prescriptions of oral analgesics for the treatment of pain is beneficial. However, there have been few reports on the prescription status of oral analgesics from a nation-wide, large-scale prescription database in Japan. Research design and methods: The authors analyzed the prescription data of 2,042,302 patients prescribed oral analgesics in 2017. The numbers/proportions of patients prescribed oral analgesics, adherence with approved doses, co-prescription patterns, dose changes, drug adherence, and treatment-discontinuation rates were evaluated. Results: Loxoprofen was prescribed to 32.5% of the patients, followed by celecoxib, prescribed to 16.0% of patients. Acetaminophen and pregabalin were prescribed to 10.5% and 9.4% of patients, respectively. Many analgesics were prescribed at lower doses than the approved doses. The most frequently used concomitant medication was pregabalin. For duloxetine and pregabalin, high proportions of patients were prescribed these drugs for > 90 days. Conclusions: Loxoprofen was the most prescribed of the non-steroidal anti-inflammatory drugs in Japan. The information obtained provides an overview of prescribed oral analgesics in Japan and could be useful for potential research into prescribed oral analgesics in the future.
Background: Information on prescriptions of oral analgesics for the treatment of pain is beneficial. However, there have been few reports on the prescription status of oral analgesics from a nation-wide, large-scale prescription database in Japan. Research design and methods: The authors analyzed the prescription data of 2,042,302 patients prescribed oral analgesics in 2017. The numbers/proportions of patients prescribed oral analgesics, adherence with approved doses, co-prescription patterns, dose changes, drug adherence, and treatment-discontinuation rates were evaluated. Results:Loxoprofen was prescribed to 32.5% of the patients, followed by celecoxib, prescribed to 16.0% of patients. Acetaminophen and pregabalin were prescribed to 10.5% and 9.4% of patients, respectively. Many analgesics were prescribed at lower doses than the approved doses. The most frequently used concomitant medication was pregabalin. For duloxetine and pregabalin, high proportions of patients were prescribed these drugs for > 90 days. Conclusions: Loxoprofen was the most prescribed of the non-steroidal anti-inflammatory drugs in Japan. The information obtained provides an overview of prescribed oral analgesics in Japan and could be useful for potential research into prescribed oral analgesics in the future.
Authors: Luis Fernando Valladales-Restrepo; Santiago Rubio-Londoño; Luisa Fernanda Poveda-Martinez; Jorge Enrique Machado-Alba Journal: Drugs Real World Outcomes Date: 2022-07-11