Literature DB >> 31422214

Treatment for oral squamous cell carcinoma: Impact of surgeon volume on survival.

Timothy Liu1, Michael David2, Owen Ellis3, Tsu-Hui Hubert Low4, Carsten E Palme4, Jonathan Clark4, Martin Batstone5.   

Abstract

BACKGROUND: The volume-outcome relationship is a well-known phenomenon in surgical oncology. The aim of this study was to quantify the impact of surgeon volume on the treatment outcome of oral squamous cell carcinoma (OSCC) patients.
METHODS: All new OSCC cases treated with curative intent between 2008 and 2013 were included. A heterogeneous set of predictor variables was collected, including patient, tumour and treatment factors. The outcomes of interest were recurrence-free survival (RFS), overall survival (OS) and disease-specific survival (DSS). To investigate the cut-off in surgeon volume, the number of OSCC resections was analysed in multiplies of 5 cases per annum according to DSS, using univariable regression analysis.
RESULTS: 534 cases were recruited. Independently, the negative predictors for patient survival were age, perineural invasion, worsening tumour staging, and extracapsular spread. High-volume surgeon was determined to be most significant at 20 cases per annum and significantly associated with improved RFS (HR: 0.67), OS (HR: 0.44), and DSS (HR: 0.39).
CONCLUSIONS: Results from this study support the rationalisation of OSCC management at high-volume centres and in the hands of experienced surgeons for better patient survival. Head and neck surgeons should perform a minimum of 20 OSCC cases per year to maintain competency in OSCC ablation. Crown
Copyright © 2019. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Oral cancer; Squamous cell carcinoma; Surgeon; Survival; Volume

Mesh:

Year:  2019        PMID: 31422214     DOI: 10.1016/j.oraloncology.2019.06.030

Source DB:  PubMed          Journal:  Oral Oncol        ISSN: 1368-8375            Impact factor:   5.337


  4 in total

1.  Silencing of LncRNA SNHG16 Downregulates Cyclin D1 (CCND1) to Abrogate Malignant Phenotypes in Oral Squamous Cell Carcinoma (OSCC) Through Upregulating miR-17-5p.

Authors:  Qiuling Wang; Jingxin Han; Pu Xu; Xinchun Jian; Xieshan Huang; Deyu Liu
Journal:  Cancer Manag Res       Date:  2021-02-22       Impact factor: 3.989

2.  Analysis of Radiation Facility Volume and Survival in Men With Lymph Node-Positive Prostate Cancer Treated With Radiation and Androgen Deprivation Therapy.

Authors:  Sagar A Patel; Subir Goyal; Yuan Liu; Drew Moghanaki; Pretesh R Patel; Sheela Hanasoge; Vishal R Dhere; Jay W Shelton; Karen D Godette; Ashesh B Jani; Bruce Hershatter; Benjamin W Fischer-Valuck
Journal:  JAMA Netw Open       Date:  2020-12-01

Review 3.  Value and Quality of Care in Head and Neck Oncology.

Authors:  Robert P Takes; Gyorgy B Halmos; John A Ridge; Paolo Bossi; Matthias A W Merkx; Alessandra Rinaldo; Alvaro Sanabria; Ludi E Smeele; Antti A Mäkitie; Alfio Ferlito
Journal:  Curr Oncol Rep       Date:  2020-07-10       Impact factor: 5.075

4.  B4GALNT1 enhances cell proliferation and growth in oral squamous cell carcinoma via p38 and JNK MAPK pathway.

Authors:  Shaohong Jing; Zhaoming Deng; Lizhong Liang; Jun Liang
Journal:  Transl Cancer Res       Date:  2020-04       Impact factor: 1.241

  4 in total

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