Carlos A Camargo1, John Sluyter2, Alistair W Stewart2, Kay-Tee Khaw3, Carlene M M Lawes2, Les Toop4, Debbie Waayer2, Robert Scragg2. 1. Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 2. School of Population Health, University of Auckland, Auckland, New Zealand. 3. Department of Public Health and Primary Care, University of Cambridge, United Kingdom. 4. Department of General Practice, University of Otago, Christchurch, New Zealand.
Abstract
BACKGROUND: Although adults with low vitamin D status are at increased risk of acute respiratory infection (ARI), randomized controlled trials of vitamin D supplementation have provided inconsistent results. METHODS: We performed a randomized, double-blinded, placebo-controlled trial of 5110 adults aged 50-84 years. In 2011-2012, participants were randomized to an initial oral dose of 200 000 IU vitamin D3 followed by 100 000 IU monthly (n = 2558) or placebo (n = 2552) until late 2013 (median follow-up, 1.6 years). Participants reported upper and lower ARIs on monthly questionnaires. Cox models analyzed time to first ARI (upper or lower) by treatment group. RESULTS:Participants' mean age was 66 years and 58% were male; 83% were of European/other ethnicity, with the rest Maori, Polynesian, or South Asian. Mean (SD) baseline blood 25-hydroxyvitamin D [25(OH)D] level was 63 (24) nmol/L; 25% were <50 nmol/L. In a random sample (n = 441), vitamin D supplementation increased mean 25(OH)D to 135 nmol/L at 3 years, while those on placebo remained at 63 nmol/L. During follow-up, 3737 participants reported ≥1 ARI: 74.1% in the vitamin D group versus 73.7% in the placebo group. The hazard ratio for vitamin D compared with placebo was 1.01 (95% CI, 0.94, 1.07). Similar results were seen in most subgroups, including those with baseline 25(OH)D <50 nmol/L and in analyses of the upper/lower components of the ARI outcome. CONCLUSIONS:Monthly high-dose vitamin D supplementation does not prevent ARI in older adults with a low prevalence of profound vitamin D deficiency at baseline. Whether effects of daily or weekly dosing differ requires further study. CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry, identifier ACTRN12611000402943.
RCT Entities:
BACKGROUND: Although adults with low vitamin D status are at increased risk of acute respiratory infection (ARI), randomized controlled trials of vitamin D supplementation have provided inconsistent results. METHODS: We performed a randomized, double-blinded, placebo-controlled trial of 5110 adults aged 50-84 years. In 2011-2012, participants were randomized to an initial oral dose of 200 000 IU vitamin D3 followed by 100 000 IU monthly (n = 2558) or placebo (n = 2552) until late 2013 (median follow-up, 1.6 years). Participants reported upper and lower ARIs on monthly questionnaires. Cox models analyzed time to first ARI (upper or lower) by treatment group. RESULTS:Participants' mean age was 66 years and 58% were male; 83% were of European/other ethnicity, with the rest Maori, Polynesian, or South Asian. Mean (SD) baseline blood 25-hydroxyvitamin D [25(OH)D] level was 63 (24) nmol/L; 25% were <50 nmol/L. In a random sample (n = 441), vitamin D supplementation increased mean 25(OH)D to 135 nmol/L at 3 years, while those on placebo remained at 63 nmol/L. During follow-up, 3737 participants reported ≥1 ARI: 74.1% in the vitamin D group versus 73.7% in the placebo group. The hazard ratio for vitamin D compared with placebo was 1.01 (95% CI, 0.94, 1.07). Similar results were seen in most subgroups, including those with baseline 25(OH)D <50 nmol/L and in analyses of the upper/lower components of the ARI outcome. CONCLUSIONS: Monthly high-dose vitamin D supplementation does not prevent ARI in older adults with a low prevalence of profound vitamin D deficiency at baseline. Whether effects of daily or weekly dosing differ requires further study. CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry, identifier ACTRN12611000402943.
Authors: Carlos A Camargo; Les Toop; John Sluyter; Carlene M M Lawes; Debbie Waayer; Kay-Tee Khaw; Adrian R Martineau; Robert Scragg Journal: Nutrients Date: 2021-02-06 Impact factor: 5.717
Authors: David A Jolliffe; Carlos A Camargo; John D Sluyter; Mary Aglipay; John F Aloia; Davaasambuu Ganmaa; Peter Bergman; Arturo Borzutzky; Camilla T Damsgaard; Gal Dubnov-Raz; Susanna Esposito; Clare Gilham; Adit A Ginde; Inbal Golan-Tripto; Emma C Goodall; Cameron C Grant; Christopher J Griffiths; Anna Maria Hibbs; Wim Janssens; Anuradha Vaman Khadilkar; Ilkka Laaksi; Margaret T Lee; Mark Loeb; Jonathon L Maguire; Paweł Majak; David T Mauger; Semira Manaseki-Holland; David R Murdoch; Akio Nakashima; Rachel E Neale; Hai Pham; Christine Rake; Judy R Rees; Jenni Rosendahl; Robert Scragg; Dheeraj Shah; Yoshiki Shimizu; Steve Simpson-Yap; Geeta Trilok Kumar; Mitsuyoshi Urashima; Adrian R Martineau Journal: medRxiv Date: 2020-11-25
Authors: Friederike Maretzke; Angela Bechthold; Sarah Egert; Jana B Ernst; Debora Melo van Lent; Stefan Pilz; Jörg Reichrath; Gabriele I Stangl; Peter Stehle; Dorothee Volkert; Michael Wagner; Julia Waizenegger; Armin Zittermann; Jakob Linseisen Journal: Nutrients Date: 2020-03-31 Impact factor: 5.717