Literature DB >> 31419493

Limited predictive value of TFAM in mitochondrial biogenesis.

Natalya Kozhukhar1, Mikhail F Alexeyev2.   

Abstract

Mitochondrial transcription factor A (TFAM) plays an important role in mitochondrial DNA (mtDNA) transcription and replication. In some experimental settings, TFAM expression parallels parameters of mitochondrial biogenesis, which led to a widespread acceptance of TFAM as marker of mitochondrial biogenesis. We modulated TFAM expression in several experimental systems and observed that it fails to consistently parallel mtDNA copy number and expression of mtDNA-encoded polypeptides. We suggest that the use of TFAM as a marker of mitochondrial biogenesis should be avoided outside of systems in which its performance has been carefully validated.
Copyright © 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

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Year:  2019        PMID： 31419493      PMCID： PMC6885536          DOI： 10.1016/j.mito.2019.08.001

Source DB:  PubMed          Journal:  Mitochondrion        ISSN： 1567-7249            Impact factor:   4.160


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