Pengfei Shi1, Min Zhou2, Yonggang Yang3. 1. Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street Jiangan District, Wuhan, 430014, China. 2. Department of Out-patient, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 3. Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street Jiangan District, Wuhan, 430014, China. yaqiao121031@163.com.
Abstract
BACKGROUND: This study is aimed at exploring the correlation of sirtuin 2 (SIRT2) with clinical characteristics as well as overall survival (OS) in breast cancer patients. METHODS: Totally, 296 primary breast cancer patients who underwent surgical resection were retrospectively reviewed in this study, and SIRT2 expression in tumor and adjacent tissues was determined by immunohistochemistry (IHC) and scored by semiquantitative scoring (0-12). Clinicopathological features were retrieved, and OS was calculated. RESULTS: Both SIRT2 IHC semiquantitative score and percentage of SIRT2 high expression by IHC score > 3 were lower in tumor tissues compared with adjacent tissues. Additionally, tumor SIRT2 high expression was associated with lower T stage, decreased N stage, and reduced TNM stage. Kaplan-Meier curves displayed that tumor SIRT2 high expression predicted longer OS. Univariate Cox's regression analysis showed that tumor SIRT2 high expression was associated with prolonged OS, while multivariate Cox's regression analysis displayed that tumor SIRT2 high expression was not an independent predictive factor for OS, which implied that tumor SIRT2 might predict OS indirectly through the interaction of tumor features (such as TNM stage) in breast cancer patients. CONCLUSION: SIRT2 expression is lower in tumor tissues compared with adjacent tissues, and tumor SIRT2 high expression correlates with lower T stage, decreased N stage, reduced TNM stage, and longer OS in breast cancer patients.
BACKGROUND: This study is aimed at exploring the correlation of sirtuin 2 (SIRT2) with clinical characteristics as well as overall survival (OS) in breast cancerpatients. METHODS: Totally, 296 primary breast cancerpatients who underwent surgical resection were retrospectively reviewed in this study, and SIRT2 expression in tumor and adjacent tissues was determined by immunohistochemistry (IHC) and scored by semiquantitative scoring (0-12). Clinicopathological features were retrieved, and OS was calculated. RESULTS: Both SIRT2 IHC semiquantitative score and percentage of SIRT2 high expression by IHC score > 3 were lower in tumor tissues compared with adjacent tissues. Additionally, tumorSIRT2 high expression was associated with lower T stage, decreased N stage, and reduced TNM stage. Kaplan-Meier curves displayed that tumorSIRT2 high expression predicted longer OS. Univariate Cox's regression analysis showed that tumorSIRT2 high expression was associated with prolonged OS, while multivariate Cox's regression analysis displayed that tumorSIRT2 high expression was not an independent predictive factor for OS, which implied that tumorSIRT2 might predict OS indirectly through the interaction of tumor features (such as TNM stage) in breast cancerpatients. CONCLUSION:SIRT2 expression is lower in tumor tissues compared with adjacent tissues, and tumorSIRT2 high expression correlates with lower T stage, decreased N stage, reduced TNM stage, and longer OS in breast cancerpatients.
Authors: Warren Fiskus; Veena Coothankandaswamy; Jianguang Chen; Hongwei Ma; Kyungsoo Ha; Dyana T Saenz; Stephanie S Krieger; Christopher P Mill; Baohua Sun; Peng Huang; Jeffrey S Mumm; Ari M Melnick; Kapil N Bhalla Journal: Cancer Res Date: 2016-08-08 Impact factor: 12.701