| Literature DB >> 31417998 |
Akitake Yamaguchi1, Sherif J Kaldas, Solomon D Appavoo, Diego B Diaz, Andrei K Yudin.
Abstract
Macrocyclization of linear peptide precursors using the Petasis borono-Mannich reaction affords a diverse range of macrocycles with an endocyclic amine. Analysis of the corresponding macrocyclic structures underscores that the hydrogen bond between an endocyclic amine and the adjacent amide NH is a powerful control element for conformationally homogenous peptide macrocycles.Entities:
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Year: 2019 PMID： 31417998 DOI： 10.1039/c9cc05934b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222