| Literature DB >> 31416930 |
Dorothea Schulte1, Dirk Geerts2.
Abstract
MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer summarizes recent findings about MEIS protein activity and regulation in development, and discusses new insights into the role of MEIS genes in disease, focusing on the pathogenesis of solid cancers.Entities:
Keywords: Cell cycle; Embryogenesis; Epigenetic modification of chromatin; MEIS; PBX; Post-transcriptional and posttranslational control; Solid cancer
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Year: 2019 PMID: 31416930 DOI: 10.1242/dev.174706
Source DB: PubMed Journal: Development ISSN: 0950-1991 Impact factor: 6.868