| Literature DB >> 31416310 |
Zhihong Zhang, Wei Zhang, Fangyuan Kang, Fanny C F Ip, Nancy Y Ip, Rongbiao Tong.
Abstract
The asymmetric total syntheses of (-)-rhynchophylline and (+)-isorhynchophylline were achieved in 17 and 16 steps, respectively, from butanal and ethyl acrylate. Our synthesis features Carreira ring expansion to construct the tetracyclic spirooxindole core in high diastereoselectivity and the use of Bosch's chiral lactam for preparation of enantioenriched cyclic imine.Entities:
Year: 2019 PMID： 31416310 DOI： 10.1021/acs.joc.9b01977
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354