Yukishige Hashimoto1, Toshinori Matsushige2, Koji Shimonaga1, Masahiro Hosogai1, Mayumi Kaneko3, Chiaki Ono4, Tatsuya Mizoue1. 1. Department of Neurosurgery and Interventional Neuroradiology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan. 2. Department of Neurosurgery and Interventional Neuroradiology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan. Electronic address: teruteru728@hiroshima-u.ac.jp. 3. Department of Pathology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan. 4. Department of Radiology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Abstract
BACKGROUND: Recent studies have suggested that magnetic resonance vessel wall imaging (VWI) can visualize thickened intracranial aneurysm wall. We aimed to investigate correlations between VWI findings and intraoperative aneurysm wall features based on the hypothesis that VWI can visualize atherosclerotic changes in unruptured intracranial aneurysm (UIA) walls. METHODS: A total of 36 microsurgically treated UIAs were retrospectively reviewed. All aneurysms underwent VWI before microsurgical clipping, and fusion images with time-of-flight magnetic resonance angiography were created to localize aneurysm wall enhancement (AWE) lesions. Intraoperatively, 2 neurosurgeons who were blinded to the VWI findings evaluated the aneurysm wall features, giving each aneurysm an atherosclerosis score on a 5-point scale (5: yellowish, 4: whitish, 3: normal, 2: slightly reddish, 1: reddish). We defined atherosclerotic lesions as those having average scores ≥4. We evaluated the rate of correspondence between AWE lesions and atherosclerotic lesions, and the factors associated with AWE. RESULTS: Sixteen of the 36 UIAs (44%) were identified as AWE. The sensitivity, specificity, positive predictive value, and negative predictive value of correspondence between AWE lesions and atherosclerotic lesions were 79%, 94%, 94%, and 80%, respectively. The average atherosclerosis scores (4.2 ± 0.5 vs. 2.7 ± 0.9; P < 0.001) were significantly higher in aneurysms with AWE. Twelve of 16 UIAs with wall enhancement had wall thinning adjacent to the part with AWE. CONCLUSIONS: AWE lesions corresponded with intraoperatively confirmed atherosclerotic lesions of UIAs. Detecting these lesions would be valuable in exploring UIAs with wall degeneration.
BACKGROUND: Recent studies have suggested that magnetic resonance vessel wall imaging (VWI) can visualize thickened intracranial aneurysm wall. We aimed to investigate correlations between VWI findings and intraoperative aneurysm wall features based on the hypothesis that VWI can visualize atherosclerotic changes in unruptured intracranial aneurysm (UIA) walls. METHODS: A total of 36 microsurgically treated UIAs were retrospectively reviewed. All aneurysms underwent VWI before microsurgical clipping, and fusion images with time-of-flight magnetic resonance angiography were created to localize aneurysm wall enhancement (AWE) lesions. Intraoperatively, 2 neurosurgeons who were blinded to the VWI findings evaluated the aneurysm wall features, giving each aneurysm an atherosclerosis score on a 5-point scale (5: yellowish, 4: whitish, 3: normal, 2: slightly reddish, 1: reddish). We defined atherosclerotic lesions as those having average scores ≥4. We evaluated the rate of correspondence between AWE lesions and atherosclerotic lesions, and the factors associated with AWE. RESULTS: Sixteen of the 36 UIAs (44%) were identified as AWE. The sensitivity, specificity, positive predictive value, and negative predictive value of correspondence between AWE lesions and atherosclerotic lesions were 79%, 94%, 94%, and 80%, respectively. The average atherosclerosis scores (4.2 ± 0.5 vs. 2.7 ± 0.9; P < 0.001) were significantly higher in aneurysms with AWE. Twelve of 16 UIAs with wall enhancement had wall thinning adjacent to the part with AWE. CONCLUSIONS: AWE lesions corresponded with intraoperatively confirmed atherosclerotic lesions of UIAs. Detecting these lesions would be valuable in exploring UIAs with wall degeneration.
Authors: Ashrita Raghuram; Alberto Varon; Sebastian Sanchez; Daizo Ishii; Chaorong Wu; Vincent A Magnotta; David M Hasan; Timothy R Koscik; Edgar A Samaniego Journal: Stroke Vasc Interv Neurol Date: 2022-05-08
Authors: S Hadad; F Mut; B J Chung; J A Roa; A M Robertson; D M Hasan; E A Samaniego; J R Cebral Journal: AJNR Am J Neuroradiol Date: 2020-12-24 Impact factor: 3.825