| Literature DB >> 31415800 |
Yi-Ling Yang1, Wei Li2, Hao Wang2, Li Yang2, Jing-Zhe Yuan2, Cai-Hong Cai2, Hui-Qin Chen2, Wen-Hua Dong2, Xu-Po Ding2, Bei Jiang1, Attila Mándi3, Tibor Kurtán3, Wen-Li Mei4, Hao-Fu Dai5.
Abstract
Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was determined by single-crystal X-ray diffraction, while TDDFT-ECD method was applied for 6. Compounds 4 and 5 displayed significant inhibitory activities toward α-glucosidase with IC50 values of 0.22 and 1.99 mM, respectively.Entities:
Keywords: Aquilaria sp.; Prezizaane; Sesquiterpenoid; TDDFT-ECD; α-Glucosidase inhibitory activity
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Year: 2019 PMID： 31415800 DOI： 10.1016/j.fitote.2019.104301
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882