| Literature DB >> 3141565 |
S W Edwards1, J E Say, V Hughes.
Abstract
The effect of purified human interferon-gamma on the responsiveness of human neutrophils was investigated. Pre-incubation of neutrophils with 100 U interferon ml-1 for 10 min at 37 degrees C resulted in a 2.5-fold increase in N-formylmethionyl-leucyl-phenylalanine-stimulated reactive oxygen metabolite generation (as assayed by luminol-dependent chemiluminescence). Pre-treatment of neutrophils with interferon also potentiated their ability to kill Staphylococcus aureus, and thus it is proposed that this lymphokine may also enhance neutrophil function in vivo under certain pathological conditions.Entities:
Mesh：
Substances：
Year: 1988 PMID： 3141565 DOI： 10.1099/00221287-134-1-37
Source DB: PubMed Journal: J Gen Microbiol ISSN： 0022-1287