Literature DB >> 31414144

VEGF-A and blood vessels: a beta cell perspective.

Willem Staels1,2, Yves Heremans1, Harry Heimberg1, Nico De Leu3,4,5.   

Abstract

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult pancreas, islets depend on their dense capillary network to adequately respond to changes in plasma glucose levels. Vascular changes contribute to the onset and progression of both type 1 and type 2 diabetes. Impaired revascularisation of islets transplanted in individuals with type 1 diabetes is linked to islet graft failure and graft loss. This review summarises our understanding of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell development, physiology and disease. In addition, the therapeutic potential of modulating VEGF-A levels in beta and beta-like cells for transplantation is discussed.

Entities:  

Keywords:  Blood vessels; Diabetes; Endothelial cells; Pancreatic beta cells; Review; VEGF-A

Mesh：

Substances：

Year:  2019        PMID： 31414144     DOI： 10.1007/s00125-019-4969-z

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  66 in total

Review 1.  VEGF in Signaling and Disease: Beyond Discovery and Development.

Authors:  Rajendra S Apte; Daniel S Chen; Napoleone Ferrara
Journal:  Cell       Date:  2019-03-07       Impact factor: 41.582

2.  Blood vessels restrain pancreas branching, differentiation and growth.

Authors:  Judith Magenheim; Ohad Ilovich; Alon Lazarus; Agnes Klochendler; Oren Ziv; Roni Werman; Ayat Hija; Ondine Cleaver; Eyal Mishani; Eli Keshet; Yuval Dor
Journal:  Development       Date:  2011-09-28       Impact factor: 6.868

3.  Prolongation of islet graft survival using concomitant transplantation of islets and vascular endothelial cells in diabetic rats.

Authors:  H-J Song; W-J Xue; Y Li; X-H Tian; X-M Ding; X-S Feng; Y Song; P-X Tian
Journal:  Transplant Proc       Date:  2010-09       Impact factor: 1.066

4.  Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation.

Authors:  Willem Staels; Yannick Verdonck; Yves Heremans; Gunter Leuckx; Sofie De Groef; Carlo Heirman; Eelco de Koning; Conny Gysemans; Kris Thielemans; Luc Baeyens; Harry Heimberg; Nico De Leu
Journal:  Diabetologia       Date:  2018-05-22       Impact factor: 10.122

5.  Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.

Authors:  Hideyuki Yoshitomi; Kenneth S Zaret
Journal:  Development       Date:  2004-01-21       Impact factor: 6.868

6.  Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis.

Authors:  Dongming Su; Nan Zhang; Jing He; Shen Qu; Sandra Slusher; Rita Bottino; Suzanne Bertera; Jonathan Bromberg; H Henry Dong
Journal:  Diabetes       Date:  2007-06-27       Impact factor: 9.461

7.  Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.

Authors:  Kimberly G Riley; Raymond C Pasek; Matthew F Maulis; Jennifer Peek; Fabrizio Thorel; David R Brigstock; Pedro L Herrera; Maureen Gannon
Journal:  Diabetes       Date:  2014-11-12       Impact factor: 9.461

8.  Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass.

Authors:  Judith Agudo; Eduard Ayuso; Veronica Jimenez; Alba Casellas; Cristina Mallol; Ariana Salavert; Sabrina Tafuro; Mercè Obach; Albert Ruzo; Marta Moya; Anna Pujol; Fatima Bosch
Journal:  Diabetes       Date:  2012-09-06       Impact factor: 9.461

9.  Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis.

Authors:  H F Irving-Rodgers; A F Ziolkowski; C R Parish; Y Sado; Y Ninomiya; C J Simeonovic; R J Rodgers
Journal:  Diabetologia       Date:  2008-07-17       Impact factor: 10.122

10.  Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice.

Authors:  Atsushi Obata; Tomohiko Kimura; Yoshiyuki Obata; Masashi Shimoda; Tomoe Kinoshita; Kenji Kohara; Seizo Okauchi; Hidenori Hirukawa; Shinji Kamei; Shuhei Nakanishi; Tomoatsu Mune; Kohei Kaku; Hideaki Kaneto
Journal:  Diabetologia       Date:  2019-05-04       Impact factor: 10.122
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  13 in total

1.  Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system.

Authors:  Shugo Sasaki; Michelle Y Y Lee; Yuka Wakabayashi; Luka Suzuki; Helena Winata; Miwa Himuro; Taka-Aki Matsuoka; Iichiro Shimomura; Hirotaka Watada; Francis C Lynn; Takeshi Miyatsuka
Journal:  Diabetologia       Date:  2022-03-03       Impact factor: 10.122

Review 2.  Interactions between islets and regulatory immune cells in health and type 1 diabetes.

Authors:  Matthew A Budd; Mahdis Monajemi; Sarah J Colpitts; Sarah Q Crome; C Bruce Verchere; Megan K Levings
Journal:  Diabetologia       Date:  2021-09-22       Impact factor: 10.122

Review 3.  Recapitulating pancreatic cell-cell interactions through bioengineering approaches: the momentous role of non-epithelial cells for diabetes cell therapy.

Authors:  Zahra Ghezelayagh; Mahsa Zabihi; Mohammad Kazemi Ashtiani; Zeinab Ghezelayagh; Francis C Lynn; Yaser Tahamtani
Journal:  Cell Mol Life Sci       Date:  2021-10-06       Impact factor: 9.261

Review 4.  Strategies for durable β cell replacement in type 1 diabetes.

Authors:  Todd M Brusko; Holger A Russ; Cherie L Stabler
Journal:  Science       Date:  2021-07-30       Impact factor: 63.714

5.  Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Authors:  Carolina G Downie; Sofia F Dimos; Stephanie A Bien; Yao Hu; Burcu F Darst; Linda M Polfus; Yujie Wang; Genevieve L Wojcik; Ran Tao; Laura M Raffield; Nicole D Armstrong; Hannah G Polikowsky; Jennifer E Below; Adolfo Correa; Marguerite R Irvin; Laura J F Rasmussen-Torvik; Christopher S Carlson; Lawrence S Phillips; Simin Liu; James S Pankow; Stephen S Rich; Jerome I Rotter; Steven Buyske; Tara C Matise; Kari E North; Christy L Avery; Christopher A Haiman; Ruth J F Loos; Charles Kooperberg; Mariaelisa Graff; Heather M Highland
Journal:  Diabetologia       Date:  2021-12-24       Impact factor: 10.460

Review 6.  Anti-Angiogenic Therapy in the Treatment of Non-Small Cell Lung Cancer.

Authors:  Wentao Tian; Chenghui Cao; Long Shu; Fang Wu
Journal:  Onco Targets Ther       Date:  2020-11-24       Impact factor: 4.147

Review 7.  Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Authors:  Stephanie Bourgeois; Toshiaki Sawatani; Annelore Van Mulders; Nico De Leu; Yves Heremans; Harry Heimberg; Miriam Cnop; Willem Staels
Journal:  Cells       Date:  2021-01-19       Impact factor: 6.600

Review 8.  Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease.

Authors:  Sina Stucker; Jessica De Angelis; Anjali P Kusumbe
Journal:  Front Physiol       Date:  2021-03-09       Impact factor: 4.566

9.  Transcriptional profiles of human islet and exocrine endothelial cells in subjects with or without impaired glucose metabolism.

Authors:  Alexander Jonsson; Anders Hedin; Malin Müller; Oskar Skog; Olle Korsgren
Journal:  Sci Rep       Date:  2020-12-18       Impact factor: 4.379

10.  Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway.

Authors:  Chengjun Hu; Zifang Wu; Zihao Huang; Xiangyu Hao; Shuqi Wang; Jinping Deng; Yulong Yin; Chengquan Tan
Journal:  Redox Biol       Date:  2021-06-18       Impact factor: 11.799
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