Jagadeesh Kumar Venkatesan1, Ana Rey-Rico1,2, Magali Cucchiarini1. 1. 1Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr, Bldg 37, 66421 Homburg/Saar, Germany. 2. 2Cell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, Campus de A Coruña, 15071 A Coruña, Spain.
Abstract
Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by detrimental responses in the host against such vectors (immunogenic responses, vector dissemination to nontarget locations). Combining viral gene therapy techniques with tissue engineering procedures may offer strong tools to improve the current systems for applications in vivo. Methods: The goal of this work is to provide an overview of the most recent systems exploiting biomaterial technologies and therapeutic viral gene transfer in human orthopaedic regenerative medicine. Results: Integration of tissue engineering platforms with viral gene vectors is an active area of research in orthopaedics as a means to overcome the obstacles precluding effective viral gene therapy. Conclusions: In light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine.
Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by detrimental responses in the host against such vectors (immunogenic responses, vector dissemination to nontarget locations). Combining viral gene therapy techniques with tissue engineering procedures may offer strong tools to improve the current systems for applications in vivo. Methods: The goal of this work is to provide an overview of the most recent systems exploiting biomaterial technologies and therapeutic viral gene transfer in human orthopaedic regenerative medicine. Results: Integration of tissue engineering platforms with viral gene vectors is an active area of research in orthopaedics as a means to overcome the obstacles precluding effective viral gene therapy. Conclusions: In light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine.
Authors: Franklin T Moutos; Katherine A Glass; Sarah A Compton; Alison K Ross; Charles A Gersbach; Farshid Guilak; Bradley T Estes Journal: Proc Natl Acad Sci U S A Date: 2016-07-18 Impact factor: 11.205
Authors: Brett Peterson; Jeffrey Zhang; Roberto Iglesias; Michael Kabo; Marc Hedrick; Prosper Benhaim; Jay R Lieberman Journal: Tissue Eng Date: 2005 Jan-Feb
Authors: Louise L Southwood; David D Frisbie; Chris E Kawcak; Steven C Ghivizzani; Chris H Evans; C Wayne McIlwraith Journal: J Orthop Res Date: 2004-01 Impact factor: 3.494
Authors: Charles H Rundle; Donna D Strong; Shin-Tai Chen; Thomas A Linkhart; Matilda H-C Sheng; Jon E Wergedal; K-H William Lau; David J Baylink Journal: J Gene Med Date: 2008-03 Impact factor: 4.565