Literature DB >> 31413913

Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients.

Eric C Ko1, Lorenzo Galluzzi1,2,3,4.   

Abstract

CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon and dynamic changes in the peripheral T cell repertoire.

Entities:  

Keywords:  CGAS; STING; TREX1; ipilimumab; non-small cell lung carcinoma; type I interferon

Year:  2019        PMID： 31413913      PMCID： PMC6682362          DOI： 10.1080/2162402X.2019.1606624

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  14 in total

1.  Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden.

Authors:  Matthew D Hellmann; Tudor-Eliade Ciuleanu; Adam Pluzanski; Jong Seok Lee; Gregory A Otterson; Clarisse Audigier-Valette; Elisa Minenza; Helena Linardou; Sjaak Burgers; Pamela Salman; Hossein Borghaei; Suresh S Ramalingam; Julie Brahmer; Martin Reck; Kenneth J O'Byrne; William J Geese; George Green; Han Chang; Joseph Szustakowski; Prabhu Bhagavatheeswaran; Diane Healey; Yali Fu; Faith Nathan; Luis Paz-Ares
Journal:  N Engl J Med       Date:  2018-04-16       Impact factor: 91.245

2.  Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells.

Authors:  Nils-Petter Rudqvist; Karsten A Pilones; Claire Lhuillier; Erik Wennerberg; John-William Sidhom; Ryan O Emerson; Harlan S Robins; Jonathan Schneck; Silvia C Formenti; Sandra Demaria
Journal:  Cancer Immunol Res       Date:  2017-11-27       Impact factor: 11.151

Review 3.  Cytosolic DNA Sensing in Organismal Tumor Control.

Authors:  Claire Vanpouille-Box; Sandra Demaria; Silvia C Formenti; Lorenzo Galluzzi
Journal:  Cancer Cell       Date:  2018-06-28       Impact factor: 31.743

Review 4.  The hallmarks of successful anticancer immunotherapy.

Authors:  Lorenzo Galluzzi; Timothy A Chan; Guido Kroemer; Jedd D Wolchok; Alejandro López-Soto
Journal:  Sci Transl Med       Date:  2018-09-19       Impact factor: 17.956

Review 5.  SnapShot: CGAS-STING Signaling.

Authors:  Lorenzo Galluzzi; Claire Vanpouille-Box; Samuel F Bakhoum; Sandra Demaria
Journal:  Cell       Date:  2018-03-22       Impact factor: 41.582

Review 6.  Control of Metastasis by NK Cells.

Authors:  Alejandro López-Soto; Segundo Gonzalez; Mark J Smyth; Lorenzo Galluzzi
Journal:  Cancer Cell       Date:  2017-08-14       Impact factor: 31.743

Review 7.  Using immunotherapy to boost the abscopal effect.

Authors:  Wilfred Ngwa; Omoruyi Credit Irabor; Jonathan D Schoenfeld; Jürgen Hesser; Sandra Demaria; Silvia C Formenti
Journal:  Nat Rev Cancer       Date:  2018-02-16       Impact factor: 60.716

8.  Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial.

Authors:  Encouse B Golden; Arpit Chhabra; Abraham Chachoua; Sylvia Adams; Martin Donach; Maria Fenton-Kerimian; Kent Friedman; Fabio Ponzo; James S Babb; Judith Goldberg; Sandra Demaria; Silvia C Formenti
Journal:  Lancet Oncol       Date:  2015-06-18       Impact factor: 41.316

Review 9.  Systemic effects of local radiotherapy.

Authors:  Silvia C Formenti; Sandra Demaria
Journal:  Lancet Oncol       Date:  2009-07       Impact factor: 41.316

10.  DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.

Authors:  Claire Vanpouille-Box; Amandine Alard; Molykutty J Aryankalayil; Yasmeen Sarfraz; Julie M Diamond; Robert J Schneider; Giorgio Inghirami; C Norman Coleman; Silvia C Formenti; Sandra Demaria
Journal:  Nat Commun       Date:  2017-06-09       Impact factor: 14.919
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  1 in total

Review 1.  Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology.

Authors:  Isaure Vanmeerbeek; Jenny Sprooten; Dirk De Ruysscher; Sabine Tejpar; Peter Vandenberghe; Jitka Fucikova; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi; Abhishek D Garg
Journal:  Oncoimmunology       Date:  2020-01-09       Impact factor: 8.110
  1 in total

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