Literature DB >> 31413789

In Praise of Remarkably Powerful Centamolecular Therapeutic Agents.

Nicholas A Meanwell1, William R Ewing1.   

Abstract

While biological medications have addressed many important and challenging therapeutic targets, the pharmacopeia is still dominated by centamolecules. In this Viewpoint, we illustrate the impact of centamolecule drugs on mortality and morbidity due to chronic viral infections and present select examples from other disease areas that highlight some of their remarkably powerful biochemical effects.

Entities:  

Year:  2019        PMID： 31413789      PMCID： PMC6691479          DOI： 10.1021/acsmedchemlett.9b00286

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  14 in total

1.  Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.

Authors:  Nicholas A Meanwell; Mark R Krystal; Beata Nowicka-Sans; David R Langley; David A Conlon; Martin D Eastgate; Dennis M Grasela; Peter Timmins; Tao Wang; John F Kadow
Journal:  J Med Chem       Date:  2017-12-22       Impact factor: 7.446

2.  Lost in Translation: The Death of Basic Science.

Authors:  Craig W Lindsley
Journal:  ACS Chem Neurosci       Date:  2016-08-17       Impact factor: 4.418

3.  Forecasting the morbidity and mortality associated with prevalent cases of pre-cirrhotic chronic hepatitis C in the United States.

Authors:  David B Rein; John S Wittenborn; Cindy M Weinbaum; Miriam Sabin; Bryce D Smith; Sarah B Lesesne
Journal:  Dig Liver Dis       Date:  2010-06-17       Impact factor: 4.088

4.  Reduction in liver transplant wait-listing in the era of direct-acting antiviral therapy.

Authors:  Jennifer A Flemming; W Ray Kim; Carol L Brosgart; Norah A Terrault
Journal:  Hepatology       Date:  2016-12-24       Impact factor: 17.425

Review 5.  The biology of thrombopoietin and thrombopoietin receptor agonists.

Authors:  David J Kuter
Journal:  Int J Hematol       Date:  2013-07-03       Impact factor: 2.490

6.  A short synthetic route to (+)-austamide, (+)-deoxyisoaustamide, and (+)-hydratoaustamide from a common precursor by a novel palladium-mediated indole --> dihydroindoloazocine cyclization.

Authors:  Phil S Baran; E J Corey
Journal:  J Am Chem Soc       Date:  2002-07-10       Impact factor: 15.419

7.  The effect of new drug approvals on HIV mortality in the US, 1987-1998.

Authors:  Frank R Lichtenberg
Journal:  Econ Hum Biol       Date:  2003-06       Impact factor: 2.184

8.  Drug-Target Kinetics in Drug Discovery.

Authors:  Peter J Tonge
Journal:  ACS Chem Neurosci       Date:  2017-07-14       Impact factor: 4.418

Review 9.  Overview of Current Drugs and Molecules in Development for Spinal Muscular Atrophy Therapy.

Authors:  Hannah K Shorrock; Thomas H Gillingwater; Ewout J N Groen
Journal:  Drugs       Date:  2018-03       Impact factor: 9.546

10.  Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

Authors:  Jin-Hua Sun; Donald R O'Boyle; Robert A Fridell; David R Langley; Chunfu Wang; Susan B Roberts; Peter Nower; Benjamin M Johnson; Frederic Moulin; Michelle J Nophsker; Ying-Kai Wang; Mengping Liu; Karen Rigat; Yong Tu; Piyasena Hewawasam; John Kadow; Nicholas A Meanwell; Mark Cockett; Julie A Lemm; Melissa Kramer; Makonen Belema; Min Gao
Journal:  Nature       Date:  2015-11-04       Impact factor: 49.962
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