Literature DB >> 31413447

Phosphotyrosine - a new protein modification.

Tony Hunter1.   

Abstract

Tyrosine protein kinases carry out a newly described form of protein modification - phosphorylation of tyrosine residues. The transforming proteins of certain tumor viruses are tyrosine protein kinases and unscheduled phosphorylation of tyrosine in cellular proteins appears to be crucial for malignant transformation by these viruses. A primary effect of two cellular growth factors is to activate intracellular tyrosine protein kinases.

Entities:  

Year:  1982        PMID： 31413447      PMCID： PMC6693627          DOI： 10.1016/0968-0004(82)90035-4

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  18 in total

1.  Transformation by Rous sarcoma virus: effects of src gene expression on the synthesis and phosphorylation of cellular polypeptides.

Authors:  K Radke; G S Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

2.  Protein kinase activity associated with the avian sarcoma virus src gene product.

Authors:  M S Collett; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

3.  Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein.

Authors:  A D Levinson; H Oppermann; L Levintow; H E Varmus; J M Bishop
Journal:  Cell       Date:  1978-10       Impact factor: 41.582

4.  Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

Authors:  J A Cooper; T Hunter
Journal:  Mol Cell Biol       Date:  1981-02       Impact factor: 4.272

5.  Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten.

Authors:  A H Ross; D Baltimore; H N Eisen
Journal:  Nature       Date:  1981-12-17       Impact factor: 49.962

6.  Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase.

Authors:  T M Gilmer; R L Erikson
Journal:  Nature       Date:  1981-12-24       Impact factor: 49.962

7.  An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates.

Authors:  W Eckhart; M A Hutchinson; T Hunter
Journal:  Cell       Date:  1979-12       Impact factor: 41.582

8.  Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn.

Authors:  D L Brautigan; P Bornstein; B Gallis
Journal:  J Biol Chem       Date:  1981-07-10       Impact factor: 5.157

9.  Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells.

Authors:  T Hunter; J A Cooper
Journal:  Cell       Date:  1981-06       Impact factor: 41.582

10.  Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

Authors:  H Ushiro; S Cohen
Journal:  J Biol Chem       Date:  1980-09-25       Impact factor: 5.157
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