| Literature DB >> 31411483 |
Xin-Hua Gao1, Yao-Yue Fan1, Qun-Fang Liu1, Sang-Hyun Cho2, Guido F Pauli2, Shao-Nong Chen2, Jian-Min Yue1.
Abstract
The suadimins A-C (1-3) from Melodinus suaveolens are the first example of monoterpenoid quinoline alkaloid dimers featuring an unprecedented carbon skeleton. Their structures and absolute configurations were established on the basis of extensive spectroscopic analyses, electric circular dichroism (ECD), and X-ray crystallography. Suadimin A showed significant antimycobacterial activity in vitro with an MIC90 of 6.76 μM against the H37Rv strain of M. tuberculosis.Entities:
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Year: 2019 PMID： 31411483 DOI： 10.1021/acs.orglett.9b02630
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005