Yannick Molgat-Seon1,2,3,4, Paolo B Dominelli5, Jordan A Guenette2,3,4, A William Sheel4. 1. Department of Kinesiology and Applied Health, Gupta Faculty of Kinesiology and Applied Health, University of Winnipeg, Winnipeg, MB, Canada. 2. Centre for Heart and Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada. 3. Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. 4. School of Kinesiology, Faculty of Education, University of British Columbia, Vancouver, BC, Canada. 5. Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Abstract
NEW FINDINGS: What is the central question of this study? What is the effect of age and sex on the resistive and viscoelastic components of work of breathing (Wb ) during exercise? What is the main finding and its importance? The resistive and viscoelastic components of Wb were higher in older adults, regardless of sex. The resistive, but not viscoelastic, component of Wb was higher in females than in males, regardless of age. These findings contribute to improving our understanding of the effects of ageing and sex on the mechanical ventilatory response to exercise. ABSTRACT: Healthy ageing and biological sex each affect the work of breathing (Wb ) for a given minute ventilation ( V ̇ E ). Age-related structural changes to the respiratory system lead to an increase in both the resistive and viscoelastic components of Wb ; however, it is unclear whether healthy ageing differentially alters the mechanics of breathing in males and females. We analysed data from 22 older (60-80 years, n = 12 females) and 22 younger (20-30 years, n = 11 females) males and females that underwent an incremental cycle exercise test to exhaustion. V ̇ E and Wb were assessed at rest and throughout exercise. Wb - V ̇ E data for each participant were fitted to a non-linear equation (i.e. Wb = a V ̇ E 3 + b V ̇ E 2 ) that partitions Wb into resistive (i.e. a V ̇ E 3 ) and viscoelastic (i.e. b V ̇ E 2 ) components. We then modelled the effects of healthy ageing and biological sex on each component of Wb . Overall, the model fit was excellent (r2 : 0.99 ± 0.01). There was a significant main effect of age and sex on the resistive component of Wb (both P < 0.05), and a significant main effect of age (P < 0.001), but not sex (P = 0.309), on the viscoelastic component of Wb . No significant interactions between age and sex on a V ̇ E 3 or b V ̇ E 2 were noted (both P > 0.05). Our findings indicate that during exercise: (i) the higher total Wb in females relative to males is due to a higher resistive, but not viscoelastic, component of Wb , and (ii) regardless of sex, the higher Wb in older adults relative to younger adults is due to higher resistive and viscoelastic components of Wb .
NEW FINDINGS: What is the central question of this study? What is the effect of age and sex on the resistive and viscoelastic components of work of breathing (Wb ) during exercise? What is the main finding and its importance? The resistive and viscoelastic components of Wb were higher in older adults, regardless of sex. The resistive, but not viscoelastic, component of Wb was higher in females than in males, regardless of age. These findings contribute to improving our understanding of the effects of ageing and sex on the mechanical ventilatory response to exercise. ABSTRACT: Healthy ageing and biological sex each affect the work of breathing (Wb ) for a given minute ventilation ( V ̇ E ). Age-related structural changes to the respiratory system lead to an increase in both the resistive and viscoelastic components of Wb ; however, it is unclear whether healthy ageing differentially alters the mechanics of breathing in males and females. We analysed data from 22 older (60-80 years, n = 12 females) and 22 younger (20-30 years, n = 11 females) males and females that underwent an incremental cycle exercise test to exhaustion. V ̇ E and Wb were assessed at rest and throughout exercise. Wb - V ̇ E data for each participant were fitted to a non-linear equation (i.e. Wb = a V ̇ E 3 + b V ̇ E 2 ) that partitions Wb into resistive (i.e. a V ̇ E 3 ) and viscoelastic (i.e. b V ̇ E 2 ) components. We then modelled the effects of healthy ageing and biological sex on each component of Wb . Overall, the model fit was excellent (r2 : 0.99 ± 0.01). There was a significant main effect of age and sex on the resistive component of Wb (both P < 0.05), and a significant main effect of age (P < 0.001), but not sex (P = 0.309), on the viscoelastic component of Wb . No significant interactions between age and sex on a V ̇ E 3 or b V ̇ E 2 were noted (both P > 0.05). Our findings indicate that during exercise: (i) the higher total Wb in females relative to males is due to a higher resistive, but not viscoelastic, component of Wb , and (ii) regardless of sex, the higher Wb in older adults relative to younger adults is due to higher resistive and viscoelastic components of Wb .
Authors: Joshua C Weavil; Taylor S Thurston; Thomas J Hureau; Jayson R Gifford; Soheil Aminizadeh; Hsuan-Yu Wan; Robert H Jenkinson; Markus Amann Journal: J Appl Physiol (1985) Date: 2022-01-27
Authors: Carli M Peters; Yannick Molgat-Seon; Paolo B Dominelli; Anthony M D Lee; Pierre Lane; Stephen Lam; Andrew W Sheel Journal: Physiol Rep Date: 2021-01