Literature DB >> 3140616

Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig.

G P Anderson1, M R Fennessy.   

Abstract

Inhibitors of platelet activating factor (PAF) and leukotriene synthesis or action are of interest as potential anti-asthmatic drugs. The present study outlines evidence suggesting an interaction between PAF and lipoxygenase products mediating increased airways responsiveness to histamine in vivo.

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Year:  1988        PMID： 3140616     DOI： 10.1007/978-3-0348-9156-1_14

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN： 0379-0363


  2 in total

1.  Effect of a 5-lipoxygenase inhibitor, ZM 230487, on cutaneous allergic inflammation in the guinea-pig.

Authors:  M M Teixeira; P G Hellewell
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

Review 2.  The contribution of platelet-activating factor to allergen-induced eosinophil infiltration and bronchial hyperresponsiveness.

Authors:  C P Page
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880
  2 in total

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