The basic repeating modules of the cerebral cortical circuit.

The fundamental organization of the cerebral cortical circuit is still poorly understood. In particular, it is unclear whether the diverse cell types form modular units that are repeated across the cortex. We discovered that the major cell types in cortical layer 5 form a lattice structure. Distinct types of excitatory and inhibitory neurons form cell type-specific radial clusters termed microcolumns. Microcolumns are present in diverse cortical areas, such as the visual, motor, and language areas, and are organized into periodic hexagonal lattice structures. Individual microcolumns have modular synaptic circuits and exhibit modular neuronal activity, suggesting that each of them functions as an information processing unit. Microcolumn development is suggested to be independent of cell lineage but coordinated by gap junctions. Thus, neurons in cortical layer 5 organize into a brainwide lattice structure of functional microcolumns, suggesting that parallel processing by massively repeated microcolumns underlie diverse cortical functions, such as sensory perception, motor control, and language processing.