Alain Lekoubou1, Kinfe G Bishu2, Bruce Ovbiagele3. 1. Department of Neurology, Medical University of South Carolina, Charleston, SC, USA. Electronic address: alekouboulooti@pennstatehealth.psu.edu. 2. Department of Medicine, Medical University of South Carolina, Charleston, SC, USA; Section of Health Systems Research and Policy, Medical University of South Carolina, Charleston, SC, USA. 3. Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Abstract
OBJECTIVE: Seizures are frequent among stroke patients. The goal of this study was to provide updated trends in seizures prevalence and mortality among hospitalized stroke patients. METHODS: Data from the National Inpatient Sample was used to estimate trends in seizures prevalence among stroke patients as well as mortality by seizures status, between 2006 and 2014. We used a logistic regression model to examine the association between seizures and mortality, accounting for extraneous factors. RESULTS: Overall 372,957 patients (6%) stroke patients had a secondary diagnosis of seizures. We found 29% higher odds of in-hospital death among stroke patients with a secondary diagnosis of seizures. The prevalence of seizures was more than two times higher among patients with hemorrhagic stroke (11.4%) compared to those with ischemic strokes (4.8%). The prevalence of seizures among stroke patients was 6.6% and 6.2% for all strokes, 12.6% and 12% for hemorrhagic strokes, and 5.3% and 5% for ischemic strokes respectively in 2006 and 2014. Although there was a steady decline in both groups, mortality rate among hospitalized stroke patients with seizures was consistently higher than in those without seizures for all strokes, ischemic strokes, and hemorrhagic strokes. Compared to patients with ischemic stroke and seizures, mortality rate was higher among patients with hemorrhagic stroke and seizures. SIGNIFICANCE: Seizures were present in nearly one out of 15 patients hospitalized for stroke and were more frequent among those with hemorrhagic stroke. There was a decline in mortality among stroke patients during the study period, which remained significantly higher in patients with seizures than in patients without seizures, and in those with hemorrhagic stroke compared to those with ischemic stroke.
OBJECTIVE:Seizures are frequent among strokepatients. The goal of this study was to provide updated trends in seizures prevalence and mortality among hospitalized strokepatients. METHODS: Data from the National Inpatient Sample was used to estimate trends in seizures prevalence among strokepatients as well as mortality by seizures status, between 2006 and 2014. We used a logistic regression model to examine the association between seizures and mortality, accounting for extraneous factors. RESULTS: Overall 372,957 patients (6%) strokepatients had a secondary diagnosis of seizures. We found 29% higher odds of in-hospital death among strokepatients with a secondary diagnosis of seizures. The prevalence of seizures was more than two times higher among patients with hemorrhagic stroke (11.4%) compared to those with ischemic strokes (4.8%). The prevalence of seizures among strokepatients was 6.6% and 6.2% for all strokes, 12.6% and 12% for hemorrhagic strokes, and 5.3% and 5% for ischemic strokes respectively in 2006 and 2014. Although there was a steady decline in both groups, mortality rate among hospitalized strokepatients with seizures was consistently higher than in those without seizures for all strokes, ischemic strokes, and hemorrhagic strokes. Compared to patients with ischemic stroke and seizures, mortality rate was higher among patients with hemorrhagic stroke and seizures. SIGNIFICANCE: Seizures were present in nearly one out of 15 patients hospitalized for stroke and were more frequent among those with hemorrhagic stroke. There was a decline in mortality among strokepatients during the study period, which remained significantly higher in patients with seizures than in patients without seizures, and in those with hemorrhagic stroke compared to those with ischemic stroke.
Authors: Edward C Mader; Vaniolky Losada; Jessica C Baity; Ebony M McKinnies; Lionel A Branch Journal: J Investig Med High Impact Case Rep Date: 2020 Jan-Dec
Authors: Aya Tabbalat; Soha Dargham; Jassim Al Suwaidi; Samar Aboulsoud; Salman Al Jerdi; Charbel Abi Khalil Journal: Sci Rep Date: 2021-04-15 Impact factor: 4.379