Domenico De Berardis1,2, Michele Fornaro3,4, Alessandro Valchera4,5,6, Gabriella Rapini1, Serena Di Natale1, Ida De Lauretis2, Nicola Serroni2, Laura Orsolini4,5,6, Carmine Tomasetti7, Massimiliano Bustini8, Alessandro Carano9, Federica Vellante2, Giampaolo Perna10,11,12, Laura Core13, Marco Alessandrini2, Silvia Fraticelli2, Giovanni Martinotti2, Massimo Di Giannantonio2. 1. NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini," ASL 4, Teramo, Italy. 2. Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy. 3. Neuroscience, Reproductive Science and Odontostolmatology, Section of Psychiatry, University School of Medicine Federico II, Naples, Italy. 4. Polyedra Research Group, Teramo, Italy. 5. School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK. 6. Villa S. Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy. 7. Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, University School of Medicine "Federico II", Naples, Italy. 8. NHS, Department of Mental Health, Rieti, Italy. 9. NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "Madonna Del Soccorso", San Benedetto del Tronto, Italy. 10. Hermanas Hospitalarias, FoRiPsi, Department of Clinical Neurosciences, Villa San Benedetto Menni, Albese con Cassano, Italy. 11. Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands. 12. Department of Psychiatry and Behavioral Sciences, Leonard Miller School of Medicine, University of Miami, Miami, Florida. 13. NHS, Department of Mental Health, Center of Mental Health, ASL 4, Giulianova, Italy.
Abstract
AIM: The present study is aimed at revaluating alexithymia, somatic sensations, resilience and their relationships with suicide ideation in drug naïve adult outpatients suffering from first episode major depression (MD). METHODS: Data of 103 adult outpatients (49 men, 56 women) with a diagnostic and statistical manual of mental disorders, 4th edition, text revision (DSM-IV-TR) diagnosis of MD were analysed. Alexithymia was measured using the 20-item Toronto Alexithymia Scale (TAS-20) and resilience with the 25 items Connor-Davidson Resilience Scale (CD-RISC) whereas depression was evaluated using the 17-item Hamilton Depression Rating Scale, somatic sensations with the Body Sensations Questionnaire and suicide ideation with Scale of Suicide Ideation (SSI). RESULTS: Gender comparisons between all demographic and clinical variables showed no significant differences in all variables. Subjects who were found positive for alexithymia showed higher scores on all clinical variables controlling for age, gender and duration of the current episode. In a linear regression model, lower scores on CD-RISC and Difficulty in Identifying Feelings dimension of TAS-20 were significantly predictive of higher scores on SSI. CONCLUSIONS: Alexithymia and low resilience were significant predictors of increased suicide ideation in a first MD episode. However, study limitations must be considered and future research needs are being discussed.
AIM: The present study is aimed at revaluating alexithymia, somatic sensations, resilience and their relationships with suicide ideation in drug naïve adult outpatients suffering from first episode major depression (MD). METHODS: Data of 103 adult outpatients (49 men, 56 women) with a diagnostic and statistical manual of mental disorders, 4th edition, text revision (DSM-IV-TR) diagnosis of MD were analysed. Alexithymia was measured using the 20-item Toronto Alexithymia Scale (TAS-20) and resilience with the 25 items Connor-Davidson Resilience Scale (CD-RISC) whereas depression was evaluated using the 17-item Hamilton Depression Rating Scale, somatic sensations with the Body Sensations Questionnaire and suicide ideation with Scale of Suicide Ideation (SSI). RESULTS: Gender comparisons between all demographic and clinical variables showed no significant differences in all variables. Subjects who were found positive for alexithymia showed higher scores on all clinical variables controlling for age, gender and duration of the current episode. In a linear regression model, lower scores on CD-RISC and Difficulty in Identifying Feelings dimension of TAS-20 were significantly predictive of higher scores on SSI. CONCLUSIONS: Alexithymia and low resilience were significant predictors of increased suicide ideation in a first MD episode. However, study limitations must be considered and future research needs are being discussed.
Authors: Jani Kajanoja; Max Karukivi; Paula Mustonen; Noora M Scheinin; Susanna Kortesluoma; Ana João Rodrigues; Hasse Karlsson; Linnea Karlsson Journal: Front Psychiatry Date: 2020-05-13 Impact factor: 4.157
Authors: Caroline W Grant; Angelina R Wilton; Rima Kaddurah-Daouk; Michelle Skime; Joanna Biernacka; Taryn Mayes; Thomas Carmody; Liewei Wang; Konstantinos Lazaridis; Richard Weinshilboum; William V Bobo; Madhukar H Trivedi; Paul E Croarkin; Arjun P Athreya Journal: Front Pharmacol Date: 2022-10-03 Impact factor: 5.988