Literature DB >> 31401845

Establishment of neurofilament light chain Simoa assay in cerebrospinal fluid and blood.

Robert Hendricks1, Dana Baker1, Jochen Brumm2, Teresa Davancaze1, Chris Harp3, Ann Herman3, H-Christian von Büdingen4, Michael Townsend5, Saloumeh K Fischer1.   

Abstract

Background: Neurofilament light (NfL) chain is an established cerebrospinal fluid (CSF) biomarker for neuroaxonal injury. The highly sensitive Quanterix Simoa™ platform is evaluated for NfL measurement in both CSF and blood. There is a need to link historical ELISA data that use bovine NfL to that of Simoa using a recombinant human (rhuman) NfL standard. Results/Methodology: The Simoa NF-light® Advantage Kit was validated for CSF and qualified for serum and plasma, using both rhuman and bovine NfL calibrators. Matched CSF, serum and plasma samples from 112 multiple sclerosis patients were analyzed using both calibrators.
Conclusion: In multiple sclerosis, there is a good correlation between blood and CSF NfL levels. A conversion factor of approximately 5:1 was established between bovine and rhuman NfL calibrators.

Entities:  

Keywords:  Alzheimer's disease (AD); Quanterix Simoa™; UmanDiagnostics Nf-Light ELISA (Uman ELISA); amyotrophic lateral sclerosis (ALS); biomarker; cerebrospinal fluid (CSF); multiple sclerosis (MS); neurodegeneration; neurofilament light (NfL) chain

Mesh：

Substances：

Year:  2019        PMID： 31401845     DOI： 10.4155/bio-2019-0163

Source DB:  PubMed          Journal:  Bioanalysis        ISSN： 1757-6180            Impact factor:   2.681


  26 in total

1.  Neurological Involvement in COVID-19 Among Non-Hospitalized Adolescents and Young Adults.

Authors:  Lise Beier Havdal; Lise Lund Berven; Joel Selvakumar; Tonje Stiansen-Sonerud; Truls Michael Leegaard; Trygve Tjade; Henrik Zetterberg; Kaj Blennow; Vegard Bruun Bratholm Wyller
Journal:  Front Neurol       Date:  2022-06-22       Impact factor: 4.086

2.  Serum Neurofilament Light Predicts Severity and Prognosis in Patients with Ischemic Stroke.

Authors:  Peng Wang; Jia Fan; Ling Yuan; Yi Nan; Shanji Nan
Journal:  Neurotox Res       Date:  2020-01-02       Impact factor: 3.911

Review 3.  An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.

Authors:  Nicholas J Ashton; Abdul Hye; Anto P Rajkumar; Antoine Leuzy; Stuart Snowden; Marc Suárez-Calvet; Thomas K Karikari; Michael Schöll; Renaud La Joie; Gil D Rabinovici; Kina Höglund; Clive Ballard; Tibor Hortobágyi; Per Svenningsson; Kaj Blennow; Henrik Zetterberg; Dag Aarsland
Journal:  Nat Rev Neurol       Date:  2020-04-22       Impact factor: 42.937

4.  Comparison of SimoaTM and EllaTM to assess serum neurofilament-light chain in multiple sclerosis.

Authors:  Audrey Gauthier; Sébastien Viel; Magali Perret; Guillaume Brocard; Romain Casey; Christine Lombard; Sabine Laurent-Chabalier; Marc Debouverie; Gilles Edan; Sandra Vukusic; Christine Lebrun-Frénay; Jérôme De Sèze; David Axel Laplaud; Giovanni Castelnovo; Olivier Gout; Aurélie Ruet; Thibault Moreau; Olivier Casez; Pierre Clavelou; Eric Berger; Hélène Zephir; Sophie Trouillet-Assant; Eric Thouvenot
Journal:  Ann Clin Transl Neurol       Date:  2021-04-08       Impact factor: 4.511

5.  Nontransgenic Guinea Pig Strains Exhibit Hallmarks of Human Brain Aging and Alzheimer's Disease.

Authors:  Devin Wahl; Julie A Moreno; Kelly S Santangelo; Qian Zhang; Maryam F Afzali; Maureen A Walsh; Robert V Musci; Alyssa N Cavalier; Karyn L Hamilton; Thomas J LaRocca
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2022-09-01       Impact factor: 6.591

Review 6.  Serum Neurofilament Light Chain Measurement in MS: Hurdles to Clinical Translation.

Authors:  Simon Thebault; Ronald A Booth; Carolina A Rush; Heather MacLean; Mark S Freedman
Journal:  Front Neurosci       Date:  2021-03-25       Impact factor: 4.677

7.  Saliva Neurofilament Light Chain Is Not a Diagnostic Biomarker for Neurodegeneration in a Mixed Memory Clinic Population.

Authors:  Helena Sophia Gleerup; Federica Sanna; Peter Høgh; Joel Simrén; Kaj Blennow; Henrik Zetterberg; Steen Gregers Hasselbalch; Nicholas J Ashton; Anja Hviid Simonsen
Journal:  Front Aging Neurosci       Date:  2021-05-10       Impact factor: 5.750

8.  Obinutuzumab-Induced B Cell Depletion Reduces Spinal Cord Pathology in a CD20 Double Transgenic Mouse Model of Multiple Sclerosis.

Authors:  Thomas Breakell; Sabine Tacke; Verena Schropp; Henrik Zetterberg; Kaj Blennow; Eduard Urich; Stefanie Kuerten
Journal:  Int J Mol Sci       Date:  2020-09-18       Impact factor: 5.923

9.  Neuroprotective Effect of Glatiramer Acetate on Neurofilament Light Chain Leakage and Glutamate Excess in an Animal Model of Multiple Sclerosis.

Authors:  Rina Aharoni; Raya Eilam; Shaul Lerner; Efrat Shavit-Stein; Amir Dori; Joab Chapman; Ruth Arnon
Journal:  Int J Mol Sci       Date:  2021-12-14       Impact factor: 5.923

10.  Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring.

Authors:  Peter A Calabresi; Douglas L Arnold; Dipen Sangurdekar; Carol M Singh; Arman Altincatal; Carl de Moor; Bob Engle; Jaya Goyal; Aaron Deykin; Suzanne Szak; Bernd C Kieseier; Richard A Rudick; Tatiana Plavina
Journal:  Mult Scler       Date:  2020-12-14       Impact factor: 6.312
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