Shadi Bagherzadeh-Azbari1, Habibolah Khazaie2, Mojtaba Zarei3, Kai Spiegelhalder4, Martin Walter5, Jeanne Leerssen6, Eus J W Van Someren6, Amir A Sepehry7, Masoud Tahmasian8. 1. Institute of Medical Sciences and Technology, Shahid Beheshti University, Tehran, Iran; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. 2. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. 3. Institute of Medical Sciences and Technology, Shahid Beheshti University, Tehran, Iran. 4. Department of Psychiatry and Psychotherapy, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. 5. Department of Psychiatry, University of Tübingen, Tübingen, Germany; Clinical Affective Neuroimaging Laboratory, Leibniz Institute for Neurobiology, Otto-von-Guericke University, Magdeburg, Germany. 6. Department of Sleep and Cognition, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA, Amsterdam, Netherlands; Departments of Psychiatry and Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, Vrije Universtiteit Amsterdam, Amsterdam UMC, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands. 7. Clinical and Counselling Psychology Program, Adler University, Vancouver, BC, Canada. 8. Institute of Medical Sciences and Technology, Shahid Beheshti University, Tehran, Iran. Electronic address: m_tahmasian@sbu.ac.ir.
Abstract
BACKGROUND: Insomnia is a common symptom of Major Depressive Disorder (MDD) and genome-wide association studies pointed to their strong genetic association. Although the prevalence of insomnia symptoms in MDD is noticeable and evidence supports their strong bidirectional association, the number of available neuroimaging findings on patients of MDD with insomnia symptoms is limited. However, such neuroimaging studies could verily improve our understanding of their shared pathophysiology and advance corresponding theories. METHODS: Based on the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guideline, we have conducted a literature search using PubMed, EMBASE, and Scopus databases and systematically explored 640 studies using various neuroimaging modalities in MDD patients with different degrees of insomnia symptoms. RESULTS: Despite inconsistencies, current findings from eight studies suggested structural and functional disturbances in several brain regions including the amygdala, prefrontal cortex and anterior cingulate cortex and insula. The aberrant functional connectivity within and between the main hubs of the salience and default mode networks could potentially yield new insights into the link between MDD and insomnia, which needs further assessment. LIMITATIONS: The number of studies reviewed herein is limited. The applied methods for assessing structural and functional neural mechanisms of insomnia and depression were variable. CONCLUSION: Neuroimaging methods demonstrated the overlapping underlying neural mechanisms between MDD and insomnia. Future studies may facilitate better understanding of their pathophysiology to allow development of specific treatment.
BACKGROUND:Insomnia is a common symptom of Major Depressive Disorder (MDD) and genome-wide association studies pointed to their strong genetic association. Although the prevalence of insomnia symptoms in MDD is noticeable and evidence supports their strong bidirectional association, the number of available neuroimaging findings on patients of MDD with insomnia symptoms is limited. However, such neuroimaging studies could verily improve our understanding of their shared pathophysiology and advance corresponding theories. METHODS: Based on the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guideline, we have conducted a literature search using PubMed, EMBASE, and Scopus databases and systematically explored 640 studies using various neuroimaging modalities in MDDpatients with different degrees of insomnia symptoms. RESULTS: Despite inconsistencies, current findings from eight studies suggested structural and functional disturbances in several brain regions including the amygdala, prefrontal cortex and anterior cingulate cortex and insula. The aberrant functional connectivity within and between the main hubs of the salience and default mode networks could potentially yield new insights into the link between MDD and insomnia, which needs further assessment. LIMITATIONS: The number of studies reviewed herein is limited. The applied methods for assessing structural and functional neural mechanisms of insomnia and depression were variable. CONCLUSION: Neuroimaging methods demonstrated the overlapping underlying neural mechanisms between MDD and insomnia. Future studies may facilitate better understanding of their pathophysiology to allow development of specific treatment.
Authors: Amnon A Berger; Emily R Sottosanti; Ariel Winnick; Joseph Keefe; Elasaf Gilbert; Jamal Hasoon; Michael E Thase; Alan D Kaye; Omar Viswanath; Ivan Urits Journal: Psychopharmacol Bull Date: 2022-02-25
Authors: Masoud Tahmasian; André Aleman; Ole A Andreassen; Zahra Arab; Marion Baillet; Francesco Benedetti; Tom Bresser; Joanna Bright; Michael W L Chee; Daphne Chylinski; Wei Cheng; Michele Deantoni; Martin Dresler; Simon B Eickhoff; Claudia R Eickhoff; Torbjørn Elvsåshagen; Jianfeng Feng; Jessica C Foster-Dingley; Habib Ganjgahi; Hans J Grabe; Nynke A Groenewold; Tiffany C Ho; Seung Bong Hong; Josselin Houenou; Benson Irungu; Neda Jahanshad; Habibolah Khazaie; Hosung Kim; Ekaterina Koshmanova; Desi Kocevska; Peter Kochunov; Oti Lakbila-Kamal; Jeanne Leerssen; Meng Li; Annemarie I Luik; Vincenzo Muto; Justinas Narbutas; Gustav Nilsonne; Victoria S O'Callaghan; Alexander Olsen; Ricardo S Osorio; Sara Poletti; Govinda Poudel; Joyce E Reesen; Liesbeth Reneman; Mathilde Reyt; Dieter Riemann; Ivana Rosenzweig; Masoumeh Rostampour; Amin Saberi; Julian Schiel; Christina Schmidt; Anouk Schrantee; Emma Sciberras; Tim J Silk; Kang Sim; Hanne Smevik; Jair C Soares; Kai Spiegelhalder; Dan J Stein; Puneet Talwar; Sandra Tamm; Giana L Teresi; Sofie L Valk; Eus Van Someren; Gilles Vandewalle; Maxime Van Egroo; Henry Völzke; Martin Walter; Rick Wassing; Frederik D Weber; Antoine Weihs; Lars Tjelta Westlye; Margaret J Wright; Mon-Ju Wu; Nathalia Zak; Mojtaba Zarei Journal: J Sleep Res Date: 2021-04-28 Impact factor: 3.981
Authors: Bomin Jeon; Faith S Luyster; Susan M Sereika; Monica M DiNardo; Judith A Callan; Eileen R Chasens Journal: J Clin Sleep Med Date: 2022-04-01 Impact factor: 4.062