Literature DB >> 3139878

Do gold drugs inhibit interleukin-1? Evidence from an in vitro lymphocyte activating factor assay.

D R Haynes1, I R Garrett, M W Whitehouse, B Vernon-Roberts.   

Abstract

The ability of some antiarthritic gold (I) compounds to inhibit the in vitro lympho-proliferative activity of human interleukin-1 (IL-1) in the lymphocyte activating factor (LAF) assay was investigated. Marked inhibition was seen at concentrations of auranofin (AF) and gold sodium thiomalate (GSTM) that correspond to gold levels found in the serum of patients receiving these drugs. This inhibition was not due to direct inactivation of the IL-1 molecule. Omitting 2-mercaptoethanol from the LAF assay potentiated the effect of GSTM. The antiproliferative effect of AF occurs almost immediately and probably reflects its direct cytotoxicity to stimulated lymphocytes.

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Year:  1988        PMID： 3139878

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  10 in total

1.  Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA.

Authors:  K D Rainsford; D R Haynes
Journal:  Inflammopharmacology       Date:  2013-07-04       Impact factor: 4.473

2.  Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity.

Authors:  A E Koch; J C Burrows; P J Polverini; M Cho; S J Leibovich
Journal:  Agents Actions       Date:  1991-11

3.  The modulation of intra-articular inflammation, cartilage matrix and bone loss in mono-articular arthritis induced by heat-killed Mycobacterium tuberculosis.

Authors:  M P Seed; C R Gardner
Journal:  Inflammopharmacology       Date:  2005       Impact factor: 4.473

4.  Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production.

Authors:  D R Haynes; S J Gadd; M W Whitehouse; G Mayrhofer; B Vernon-Roberts
Journal:  Inflamm Res       Date:  1996-04       Impact factor: 4.575

5.  Monocyte activation in early onset rheumatoid arthritis.

Authors:  I Fujii; M Shingu; M Nobunaga
Journal:  Ann Rheum Dis       Date:  1990-07       Impact factor: 19.103

6.  The prostaglandin E1 analogue, misoprostol, regulates inflammatory cytokines and immune functions in vitro like the natural prostaglandins E1, E2 and E3.

Authors:  D R Haynes; M W Whitehouse; B Vernon-Roberts
Journal:  Immunology       Date:  1992-06       Impact factor: 7.397

7.  A comparison of the disease-modifying and cytokine-regulating activities of tenidap, piroxicam and cyclosporin-A using the adjuvant-induced model of arthritis in rats.

Authors:  D R Haynes; M J Hutchens; M W Whitehouse; B Vernon-Roberts
Journal:  Inflammopharmacology       Date:  1998       Impact factor: 4.473

8.  Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites?

Authors:  D R Haynes; P F Wright; S J Gadd; M W Whitehouse; B Vernon-Roberts
Journal:  Agents Actions       Date:  1993-05

9.  Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane.

Authors:  G Yanni; M Nabil; M R Farahat; R N Poston; G S Panayi
Journal:  Ann Rheum Dis       Date:  1994-05       Impact factor: 19.103

10.  Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel.

Authors:  M W Whitehouse; T A Macrides; N Kalafatis; W H Betts; D R Haynes; J Broadbent
Journal:  Inflammopharmacology       Date:  1997       Impact factor: 5.093
  10 in total

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