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Literature DB >> 31398320

Manipulation by Methylation: Garnishing mRNAs with m⁶Am.

Abstract

In two recent publications in Molecular Cell,Boulias et al. (2019) and Sendinc et al. (2019) use complementary approaches to map m6Am modification sites transcriptome-wide and demonstrate that m6Am can repress translation while increasing the stability of a subset of low-abundance transcripts.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
RNA, Messenger

Year: 2019 PMID： 31398320 PMCID： PMC6860360 DOI： 10.1016/j.molcel.2019.07.019

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

7 in total

1. Cap-specific terminal N ⁶-methylation of RNA by an RNA polymerase II-associated methyltransferase.

Authors: Shinichiro Akichika; Seiichi Hirano; Yuichi Shichino; Takeo Suzuki; Hiroshi Nishimasu; Ryuichiro Ishitani; Ai Sugita; Yutaka Hirose; Shintaro Iwasaki; Osamu Nureki; Tsutomu Suzuki
Journal: Science Date: 2018-11-22 Impact factor: 47.728

2. Differential m⁶A, m⁶A_m, and m¹A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.

Authors: Jiangbo Wei; Fange Liu; Zhike Lu; Qili Fei; Yuxi Ai; P Cody He; Hailing Shi; Xiaolong Cui; Rui Su; Arne Klungland; Guifang Jia; Jianjun Chen; Chuan He
Journal: Mol Cell Date: 2018-09-06 Impact factor: 17.970

3. Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability.

Authors: Jan Mauer; Xiaobing Luo; Alexandre Blanjoie; Xinfu Jiao; Anya V Grozhik; Deepak P Patil; Bastian Linder; Brian F Pickering; Jean-Jacques Vasseur; Qiuying Chen; Steven S Gross; Olivier Elemento; Françoise Debart; Megerditch Kiledjian; Samie R Jaffrey
Journal: Nature Date: 2016-12-21 Impact factor: 49.962

2 in total

1. Unraveling the RNA modification code with mass spectrometry.

Authors: Richard Lauman; Benjamin A Garcia
Journal: Mol Omics Date: 2020-04-14

2. CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures.

Authors: Alison Galloway; Abdelmadjid Atrih; Renata Grzela; Edward Darzynkiewicz; Michael A J Ferguson; Victoria H Cowling
Journal: Open Biol Date: 2020-02-26 Impact factor: 6.411

2 in total

Manipulation by Methylation: Garnishing mRNAs with m⁶Am.

1. Cap-specific terminal N ⁶-methylation of RNA by an RNA polymerase II-associated methyltransferase.

2. Differential m⁶A, m⁶A_m, and m¹A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.

3. Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability.

4. PCIF1, a novel human WW domain-containing protein, interacts with the phosphorylated RNA polymerase II.

Review 5. RNA modifications modulate gene expression during development.

6. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

7. Cap-specific, terminal N⁶-methylation by a mammalian m⁶Am methyltransferase.

1. Unraveling the RNA modification code with mass spectrometry.

2. CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures.