| Literature DB >> 31398319 |
Macy L Sprunger1, Meredith E Jackrel2.
Abstract
In Mutant INS-gene-induced Diabetes of Youth (MIDY) syndrome, mutant proinsulin aggregates interfere with the folding of wild-type proinsulin in the endoplasmic reticulum, ultimately decreasing insulin secretion. In this issue of Molecular Cell, Cunningham et al. (2019) identify two mechanisms by which prohormone aggregation is prevented and cleared.Entities:
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Year: 2019 PMID： 31398319 DOI： 10.1016/j.molcel.2019.07.020
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970