Travis J Matics1,2, Neethi P Pinto1, L Nelson Sanchez-Pinto3,4. 1. Department of Pediatrics, The University of Chicago, Chicago, IL. 2. Division of Pediatric Critical Care, Department of Pediatrics, Advocate Children's Hospital, Oak Lawn, IL. 3. Division of Critical Care Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, IL. 4. Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.
Abstract
OBJECTIVES: Short-term and long-term morbidity and mortality are common following pediatric critical illness. Severe organ dysfunction is associated with significant in-hospital mortality in critically ill children; however, the performance of pediatric organ dysfunction scores as predictors of functional outcomes after critical illness has not been previously assessed. DESIGN: Secondary analysis of a prospective observational cohort. SETTING: A multidisciplinary, tertiary, academic PICU. PATIENTS: Patients less than or equal to 18 years old admitted between June 2012 and August 2012. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores during admission were calculated. The Functional Status Scale score was obtained at baseline, 6 months and 3 years following discharge. New morbidity was defined as a change in Functional Status Scale greater than or equal to 3 points from baseline. The performance of organ dysfunction scores at discriminating new morbidity or mortality at 6 months and 3 years was measured using the area under the curve. Seventy-three patients met inclusion criteria. Fourteen percent had new morbidity or mortality at 6 months and 23% at 3 years. The performance of the maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores at discriminating new morbidity or mortality was excellent at 6 months (areas under the curves 0.9 and 0.88, respectively) and good at 3 years (0.82 and 0.79, respectively). CONCLUSIONS: Severity of organ dysfunction is associated with longitudinal change in functional status and short-term and long-term development of new morbidity and mortality. Maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores during critical illness have good to excellent performance at predicting new morbidity or mortality up to 3 years after critical illness. Use of these pediatric organ dysfunction scores may be helpful for prognostication of longitudinal functional outcomes in critically ill children.
OBJECTIVES: Short-term and long-term morbidity and mortality are common following pediatric critical illness. Severe organ dysfunction is associated with significant in-hospital mortality in critically illchildren; however, the performance of pediatric organ dysfunction scores as predictors of functional outcomes after critical illness has not been previously assessed. DESIGN: Secondary analysis of a prospective observational cohort. SETTING: A multidisciplinary, tertiary, academic PICU. PATIENTS: Patients less than or equal to 18 years old admitted between June 2012 and August 2012. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores during admission were calculated. The Functional Status Scale score was obtained at baseline, 6 months and 3 years following discharge. New morbidity was defined as a change in Functional Status Scale greater than or equal to 3 points from baseline. The performance of organ dysfunction scores at discriminating new morbidity or mortality at 6 months and 3 years was measured using the area under the curve. Seventy-three patients met inclusion criteria. Fourteen percent had new morbidity or mortality at 6 months and 23% at 3 years. The performance of the maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores at discriminating new morbidity or mortality was excellent at 6 months (areas under the curves 0.9 and 0.88, respectively) and good at 3 years (0.82 and 0.79, respectively). CONCLUSIONS: Severity of organ dysfunction is associated with longitudinal change in functional status and short-term and long-term development of new morbidity and mortality. Maximum pediatric Sequential Organ Failure Assessment and Pediatric Logistic Organ Dysfunction-2 scores during critical illness have good to excellent performance at predicting new morbidity or mortality up to 3 years after critical illness. Use of these pediatric organ dysfunction scores may be helpful for prognostication of longitudinal functional outcomes in critically illchildren.
Authors: L Nelson Sanchez-Pinto; Melania M Bembea; Reid Wd Farris; Mary E Hartman; Folafoluwa O Odetola; Michael C Spaeder; R Scott Watson; Jerry J Zimmerman; Tellen D Bennett Journal: Pediatrics Date: 2022-01-01 Impact factor: 9.703
Authors: Sarah A Lau-Braunhut; Audrey M Smith; Martina A Steurer; Brittany L Murray; Hendry Sawe; Michael A Matthay; Teri Reynolds; Teresa Bleakly Kortz Journal: Front Pediatr Date: 2022-01-17 Impact factor: 3.418