Literature DB >> 31397691

Meaningful Patient-centered Outcomes 1 Year Following Cardiac Surgery.

Eric J Charles1, J Hunter Mehaffey1, Robert B Hawkins1, Sandra G Burks1, Timothy L McMurry2, Leora T Yarboro1, John A Kern1, Gorav Ailawadi1, Irving L Kron1, George J Stukenborg2, Benjamin D Kozower3.   

Abstract

OBJECTIVE: To evaluate meaningful, patient-centered outcomes including alive-at-home status and patient-reported quality of life 1 year after cardiac surgery.
BACKGROUND: Long-term patient-reported quality of life after cardiac surgery is not well understood. Current operative risk models and quality metrics focus on short-term outcomes.
METHODS: In this combined retrospective/prospective study, cardiac surgery patients at an academic institution (2014-2015) were followed to obtain vital status, living location, and patient-reported outcomes (PROs) at 1 year using the NIH Patient-Reported Outcomes Measurement Information System (PROMIS). We assessed the impact of cardiac surgery, discharge location, and Society of Thoracic Surgeons perioperative predicted risk of morbidity or mortality on 1-year outcomes.
RESULTS: A total of 782 patients were enrolled; 84.1% (658/782) were alive-at-home at 1 year. One-year PROMIS scores were global physical health (GPH) = 48.8 ± 10.2, global mental health (GMH) = 51.2 ± 9.6, and physical functioning (PF) = 45.5 ± 10.2 (general population reference = 50 ± 10). All 3 PROMIS domains at 1 year were significantly higher compared with preoperative scores (GPH: 41.7 ± 8.5, GMH: 46.9 ± 7.9, PF: 39.6 ± 9.0; all P < 0.001). Eighty-two percent of patients discharged to a facility were alive-at-home at 1 year. These patients, however, had significantly lower 1-year scores (difference: GPH = -5.1, GMH = -5.1, PF = -7.9; all P < 0.001). Higher Society of Thoracic Surgeons perioperative predicted risk was associated with significantly lower PRO at 1 year (P < 0.001).
CONCLUSIONS: Cardiac surgery results in improved PROMIS scores at 1 year, whereas discharge to a facility and increasing perioperative risk correlate with worse long-term PRO. One-year alive-at-home status and 1-year PRO are meaningful, patient-centered metrics that help define long-term quality and the benefit of cardiac surgery.
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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Year:  2021        PMID: 31397691     DOI: 10.1097/SLA.0000000000003357

Source DB:  PubMed          Journal:  Ann Surg        ISSN: 0003-4932            Impact factor:   13.787


  3 in total

Review 1.  Patient-Reported Outcomes in Cardiovascular Trials.

Authors:  Ruth Masterson Creber; Cristiano Spadaccio; Arnaldo Dimagli; Annie Myers; Brittany Taylor; Stephen Fremes
Journal:  Can J Cardiol       Date:  2021-05-08       Impact factor: 5.223

2.  Effect of Cardiac Surgery on One-Year Patient-Reported Outcomes: A Prospective Cohort Study.

Authors:  Eric J Charles; J Hunter Mehaffey; Robert B Hawkins; China J Green; Ashley Craddock; Zachary M Tyerman; Nathaniel D Larson; Irving L Kron; Gorav Ailawadi; Benjamin D Kozower
Journal:  Ann Thorac Surg       Date:  2020-12-10       Impact factor: 4.330

3.  Health-related quality of life in patients with recurrent pericarditis: results from a phase 2 study of rilonacept.

Authors:  David Lin; Allan Klein; David Cella; Anna Beutler; Fang Fang; Matt Magestro; Paul Cremer; Martin M LeWinter; Sushil Allen Luis; Antonio Abbate; Andrew Ertel; Leighann Litcher-Kelly; Brittany Klooster; John F Paolini
Journal:  BMC Cardiovasc Disord       Date:  2021-04-21       Impact factor: 2.298

  3 in total

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