CONTEXT: Recent findings have suggested a high prevalence of vitamin D deficiency or insufficiency in fibromyalgia (FM) patients despite the lack of clinical and pathophysiological evidence. OBJECTIVE: A systematic review was conducted to examine the association between vitamin D status and FM, including the effect of vitamin D supplementation. DATA SOURCE: PubMed, LILACS, Scopus, SciELO, Cochrane, and EMBASE were searched, from January 2000 to July 2018, using the descriptors "Fibromyalgia" and "Vitamin D." STUDY SELECTION: Trials including FM patients in whom vitamin D levels were assessed were eligible for inclusion. DATA EXTRACTION: Data comprised age, gender, country, aims, bias, diagnosis criteria, cutoff point, and status of vitamin D, together with FM symptoms and vitamin D supplementation protocol. RESULTS: A total of 26 articles were selected. Most of the studies were found to present unreliable control groups and small samples. Experimental data on vitamin D supplementation indicated improvement in certain FM symptoms. CONCLUSION: Prevalence of hypovitaminosis D in the FM population and the cause-effect relationship were inconclusive. Nevertheless, vitamin D supplementation may be considered as a co-adjuvant in FM therapy.
CONTEXT: Recent findings have suggested a high prevalence of vitamin D deficiency or insufficiency in fibromyalgia (FM) patients despite the lack of clinical and pathophysiological evidence. OBJECTIVE: A systematic review was conducted to examine the association between vitamin D status and FM, including the effect of vitamin D supplementation. DATA SOURCE: PubMed, LILACS, Scopus, SciELO, Cochrane, and EMBASE were searched, from January 2000 to July 2018, using the descriptors "Fibromyalgia" and "Vitamin D." STUDY SELECTION: Trials including FM patients in whom vitamin D levels were assessed were eligible for inclusion. DATA EXTRACTION: Data comprised age, gender, country, aims, bias, diagnosis criteria, cutoff point, and status of vitamin D, together with FM symptoms and vitamin D supplementation protocol. RESULTS: A total of 26 articles were selected. Most of the studies were found to present unreliable control groups and small samples. Experimental data on vitamin D supplementation indicated improvement in certain FM symptoms. CONCLUSION: Prevalence of hypovitaminosis D in the FM population and the cause-effect relationship were inconclusive. Nevertheless, vitamin D supplementation may be considered as a co-adjuvant in FM therapy.
Authors: Luis Iván Lozano-Plata; David Vega-Morales; Jorge Antonio Esquivel-Valerio; Mario Alberto Garza-Elizondo; Dionicio A Galarza-Delgado; Karina Silva-Luna; Griselda Serna-Peña; Janeth Sifuentes-Ramírez; Alfredo de Jesús Garza-Guerra; Raúl Díaz-Niño de Rivera Journal: Clin Rheumatol Date: 2021-02-10 Impact factor: 2.980
Authors: Hannah Waleed Haddad; Nikita Reddy Mallepalli; John Emerson Scheinuk; Pranav Bhargava; Elyse M Cornett; Ivan Urits; Alan David Kaye Journal: Pain Ther Date: 2021-04-28
Authors: Alejandro Martínez-Rodríguez; Jacobo Á Rubio-Arias; Domingo J Ramos-Campo; Cristina Reche-García; Belén Leyva-Vela; Yolanda Nadal-Nicolás Journal: Int J Environ Res Public Health Date: 2020-03-26 Impact factor: 3.390