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Literature DB >> 31396657

The dichotomous function of interleukin-9 in cancer diseases.

Abstract

The pleiotropic function of the cytokine IL-9 is so far described in many inflammation processes and autoimmune diseases. But its role in cancer immunology is rather diverse as it can have a pro-tumorigenic function as well as anti-tumorigenic characteristics. In various disease models of cancer, this cytokine is involved in different signaling pathways triggering the expression of proteins involved in cell growth, migration, and transformation or repressing cells from the adaptive immune system to reject tumor growth. Additionally, there are even therapeutic approaches for IL-9 in cancer development. This review will give an overview of the various roles of IL-9 in different immune organs and cells and provide an insight in the current state of research in the IL-9-dependent cancer area.

Entities: Disease Gene

Keywords: Anti-tumorigenic role; IL-9; Pro-tumorigenic role; Therapy

Mesh：

Substances：
Interleukin-9

Year: 2019 PMID： 31396657 DOI： 10.1007/s00109-019-01826-5

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

40 in total

1. Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia.

Authors: Jing Chen; Mike Petrus; Bonita R Bryant; Vinh Phuc Nguyen; Carolyn K Goldman; Richard Bamford; John C Morris; John E Janik; Thomas A Waldmann
Journal: Blood Date: 2010-09-21 Impact factor: 22.113

Review 2. IL-9 and its receptor: from signal transduction to tumorigenesis.

Authors: Laurent Knoops; Jean-Christophe Renauld
Journal: Growth Factors Date: 2004-12 Impact factor: 2.511

3. Murine bone marrow-derived mast cells as potent producers of IL-9: costimulatory function of IL-10 and kit ligand in the presence of IL-1.

Authors: M Stassen; M Arnold; L Hültner; C Müller; C Neudörfl; T Reineke; E Schmitt
Journal: J Immunol Date: 2000-06-01 Impact factor: 5.422

4. Functional and biochemical characterization of mouse P40/IL-9 receptors.

Authors: C Druez; P Coulie; C Uyttenhove; J Van Snick
Journal: J Immunol Date: 1990-10-15 Impact factor: 5.422

5. IL-9 expression by human eosinophils: regulation by IL-1beta and TNF-alpha.

Authors: A S Gounni; E Nutku; L Koussih; F Aris; J Louahed; R C Levitt; N C Nicolaides; Q Hamid
Journal: J Allergy Clin Immunol Date: 2000-09 Impact factor: 10.793

6. Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18.

Authors: B R Lauwerys; N Garot; J C Renauld; F A Houssiau
Journal: J Immunol Date: 2000-08-15 Impact factor: 5.422

7. IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma.

Authors: Li-Li Feng; Jun-Ming Gao; Pei-Pei Li; Xin Wang
Journal: J Clin Immunol Date: 2011-09-04 Impact factor: 8.317

8. Purification of MEA, a mast cell growth-enhancing activity, to apparent homogeneity and its partial amino acid sequencing.

Authors: J Moeller; L Hültner; E Schmitt; M Breuer; P Dörmer
Journal: J Immunol Date: 1990-06-01 Impact factor: 5.422

9. Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.

Authors: Karin Lange; Wolfgang Uckert; Thomas Blankenstein; Roger Nadrowitz; Cordula Bittner; Jean-Christophe Renauld; Jacques van Snick; Alfred C Feller; Hartmut Merz
Journal: Oncogene Date: 2003-01-30 Impact factor: 9.867

10. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.

Authors: Rahul Purwar; Christoph Schlapbach; Sheng Xiao; Hong Soon Kang; Wassim Elyaman; Xiaodong Jiang; Anton M Jetten; Samia J Khoury; Robert C Fuhlbrigge; Vijay K Kuchroo; Rachael A Clark; Thomas S Kupper
Journal: Nat Med Date: 2012-07-08 Impact factor: 53.440

5 in total

1. Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer.

Authors: Iwona Bednarz-Misa; Paulina Fortuna; Dorota Diakowska; Natalia Jamrozik; Małgorzata Krzystek-Korpacka
Journal: Int J Mol Sci Date: 2020-06-25 Impact factor: 5.923

5. The Role of IL-9 Polymorphisms and Serum IL-9 Levels in Carcinogenesis and Survival Rate for Laryngeal Squamous Cell Carcinoma.

Authors: Agne Pasvenskaite; Rasa Liutkeviciene; Greta Gedvilaite; Alvita Vilkeviciute; Vykintas Liutkevicius; Virgilijus Uloza
Journal: Cells Date: 2021-03-09 Impact factor: 6.600

5 in total

The dichotomous function of interleukin-9 in cancer diseases.

1. Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia.

Review 2. IL-9 and its receptor: from signal transduction to tumorigenesis.

3. Murine bone marrow-derived mast cells as potent producers of IL-9: costimulatory function of IL-10 and kit ligand in the presence of IL-1.

4. Functional and biochemical characterization of mouse P40/IL-9 receptors.

5. IL-9 expression by human eosinophils: regulation by IL-1beta and TNF-alpha.

6. Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18.

7. IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma.

8. Purification of MEA, a mast cell growth-enhancing activity, to apparent homogeneity and its partial amino acid sequencing.

9. Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.

10. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.

1. Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer.

Review 2. T_H9, T_H17, and T_H22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer.

3. Noninvasive systemic biomarkers of e-cigarette or vaping use-associated lung injury: a pilot study.

4. Bowel inflammation in cancer patients: the microbiome, antibiotics and interleukin-9.

5. The Role of IL-9 Polymorphisms and Serum IL-9 Levels in Carcinogenesis and Survival Rate for Laryngeal Squamous Cell Carcinoma.

Review 2. IL-9 and its receptor: from signal transduction to tumorigenesis.

Review 2. TH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer.

Review 2. T_H9, T_H17, and T_H22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer.