Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Whole-body autoradiography of tumor-bearing hamsters with a new tumor imaging agent, indium-111-labeled porphyrin.

Literature DB >> 3139600

Whole-body autoradiography of tumor-bearing hamsters with a new tumor imaging agent, indium-111-labeled porphyrin.

K Yamazaki¹, S Hirata, S Nakajima, Y Kubo, N Samejima, I Sakata.

Abstract

We have synthesized a new tumor imaging agent, 111In-labeled porphyrin (111In-ATN-2). In order to image transplantable pancreatic carcinoma in Syrian golden hamsters, we investigated the biodistribution of 111In-ATN-2 72 hr after injecting the agent by means of whole-body autoradiography. The efficacy of the agent was compared with that of 67Ga citrate. The images with 111In-ATN-2 were found to be clearer than those with 67Ga citrate. Tumor-to-tissue radiodistribution ratios of the former were higher than those of the latter. Thus, 111In-ATN-2 seems to be more useful for tumor diagnosis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1988 PMID： 3139600 PMCID： PMC5917598 DOI： 10.1111/j.1349-7006.1988.tb00051.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

8 in total

1. The concentration in tumor and other tissues of parenterally administered tritium- and 14-C-labeled tetraphenylporphinesulfonate.

Authors: J Winkelman; G Slater; J Grossman
Journal: Cancer Res Date: 1967-11 Impact factor: 12.701

2. [Basic study for cancer therapy with porphyrin derivatives and pheophorbide derivatives].

Authors: H Hayashi; S Nakajima; N Samejima
Journal: Hokkaido Igaku Zasshi Date: 1985-05

3. Electrophysiological studies on the cultured cells obtained from transplantable pancreatic carcinoma in Syrian golden hamsters.

Authors: N Ueda; Y Suzuki; M Utsumi; T Obara; K Okamura; M Namiki
Journal: Peptides Date: 1984 Mar-Apr Impact factor: 3.750

1 in total

1. Development of (111)In-labeled porphyrins for SPECT imaging.

Authors: Shaghayegh Sadeghi; Mohammad Mirzaei; Mohammad Rahimi; Amir R Jalilian
Journal: Asia Ocean J Nucl Med Biol Date: 2014

1 in total

Whole-body autoradiography of tumor-bearing hamsters with a new tumor imaging agent, indium-111-labeled porphyrin.

1. The concentration in tumor and other tissues of parenterally administered tritium- and 14-C-labeled tetraphenylporphinesulfonate.

2. [Basic study for cancer therapy with porphyrin derivatives and pheophorbide derivatives].

3. Electrophysiological studies on the cultured cells obtained from transplantable pancreatic carcinoma in Syrian golden hamsters.

4. Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue.

5. Photoradiation therapy of bladder tumors.

6. Delineation of a transplanted malignant melanoma with indium-111-labeled porphyrin.

7. Tumor imaging with [111In]mono-DTPA-ethyleneglycol-Ga-deuteroporphyrin.

8. Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.

1. Development of (111)In-labeled porphyrins for SPECT imaging.