| Literature DB >> 31395348 |
Mats Ljungman1, Luke Parks2, Radhika Hulbatte3, Karan Bedi3.
Abstract
Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response. This review summarizes the current understanding of the role of H3K79 methylation in transcription, how it affects genome stability and opportunities to develop impactful therapeutic interventions for cancer.Entities:
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Year: 2017 PMID： 31395348 DOI： 10.1016/j.mrrev.2017.11.001
Source DB: PubMed Journal: Mutat Res Rev Mutat Res ISSN： 1383-5742 Impact factor: 5.657