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Literature DB >> 3139457

Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells.

I Komuro¹, H Kurihara, T Sugiyama, M Yoshizumi, F Takaku, Y Yazaki.

Abstract

Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium-channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c-fos and c-myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose-dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.

Entities: Chemical Disease Gene Species

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Year: 1988 PMID： 3139457 DOI： 10.1016/0014-5793(88)80489-7

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

103 in total

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3. Involvement of nuclear factor-kappaB in endothelin-A-receptor-induced proliferation and inhibition of apoptosis.

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Review 5. Biochemical study of cyst fluid in human breast cystic disease: a review.

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6. Endothelins.

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7. Acute effect of a dual ETA-ETB receptor antagonist on pulmonary arterial vasculature in preterm lamb fetuses with surgically induced diaphragmatic hernia.

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Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells.

Review 1. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction.

Review 2. Cellular responses to hypoxia in the pulmonary circulation.

3. Involvement of nuclear factor-kappaB in endothelin-A-receptor-induced proliferation and inhibition of apoptosis.

4. Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study of rural Bangladeshi women.

Review 5. Biochemical study of cyst fluid in human breast cystic disease: a review.

6. Endothelins.

7. Acute effect of a dual ETA-ETB receptor antagonist on pulmonary arterial vasculature in preterm lamb fetuses with surgically induced diaphragmatic hernia.

Review 8. Does airway smooth muscle express an inflammatory phenotype in asthma?

9. Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1.

10. ET_B receptor contribution to vascular dysfunction in postmenopausal women.

Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells.

Review 1. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction.

Review 2. Cellular responses to hypoxia in the pulmonary circulation.

3. Involvement of nuclear factor-kappaB in endothelin-A-receptor-induced proliferation and inhibition of apoptosis.

4. Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study of rural Bangladeshi women.

Review 5. Biochemical study of cyst fluid in human breast cystic disease: a review.

6. Endothelins.

7. Acute effect of a dual ETA-ETB receptor antagonist on pulmonary arterial vasculature in preterm lamb fetuses with surgically induced diaphragmatic hernia.

Review 8. Does airway smooth muscle express an inflammatory phenotype in asthma?

9. Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1.

10. ETB receptor contribution to vascular dysfunction in postmenopausal women.

10. ET_B receptor contribution to vascular dysfunction in postmenopausal women.