Javier S Morales1, Pedro L Valenzuela2, Cecilia Rincón-Castanedo1, Alejandro Santos-Lozano3, Carmen Fiuza-Luces4, Alejandro Lucia5. 1. Universidad Europea de Madrid, Faculty of Sport Sciences, Madrid, Spain. 2. Department of Systems Byology, University of Alcalá, Madrid, Spain; Department of Sport and Health, Spanish Agency for Health Protection in Sport (AEPSAD), Madrid, Spain. 3. i+HeALTH, Department of Health Science, European University Miguel de Cervantes, Valladolid, Spain; Research Institute of the Hospital 12 de Octubre (i+12), Madrid, Spain. 4. Research Institute of the Hospital 12 de Octubre (i+12), Madrid, Spain. Electronic address: cfiuza.imas12@h12o.es. 5. Universidad Europea de Madrid, Faculty of Sport Sciences, Madrid, Spain; Research Institute of the Hospital 12 de Octubre (i+12), Madrid, Spain.
Abstract
BACKGROUND: An increase in survival rates of childhood cancer is associated with long-term health issues in survivors. METHODS: We conducted a systematic review and meta-analysis comparing health status-related endpoints in childhood cancer survivors (CCS) versus controls. RESULTS: Eighty-six studies (n = 98,480 participants, 62% CCS) were included in the review. Of these, 73 studies (n = 96,550, 63% CCS) could be meta-analyzed. CCS showed a lower left ventricular ejection and fractional shortening (SMD=-0.59 and -0.55, respectively, both p < 0.01 [n=1,824 and 1,880]), a lower HDL-cholesterol concentration (SMD=-0.48, p<0.001, n=1,378) and a higher waist-to-hip ratio (SMD=0.61, p < 0.01, n=229) than their healthy peers. No significant differences were found for the remaining endpoints. CONCLUSIONS: CCS is associated with a lower left ventricular function and HDL-cholesterol level, and a higher waist-to-hip ratio than healthy controls. These findings support the need to closely monitor the cardiometabolic health status of CCS and to implement preventive lifestyle interventions for this population.
BACKGROUND: An increase in survival rates of childhood cancer is associated with long-term health issues in survivors. METHODS: We conducted a systematic review and meta-analysis comparing health status-related endpoints in childhood cancer survivors (CCS) versus controls. RESULTS: Eighty-six studies (n = 98,480 participants, 62% CCS) were included in the review. Of these, 73 studies (n = 96,550, 63% CCS) could be meta-analyzed. CCS showed a lower left ventricular ejection and fractional shortening (SMD=-0.59 and -0.55, respectively, both p < 0.01 [n=1,824 and 1,880]), a lower HDL-cholesterol concentration (SMD=-0.48, p<0.001, n=1,378) and a higher waist-to-hip ratio (SMD=0.61, p < 0.01, n=229) than their healthy peers. No significant differences were found for the remaining endpoints. CONCLUSIONS: CCS is associated with a lower left ventricular function and HDL-cholesterol level, and a higher waist-to-hip ratio than healthy controls. These findings support the need to closely monitor the cardiometabolic health status of CCS and to implement preventive lifestyle interventions for this population.
Authors: Javier S Morales; Pedro L Valenzuela; Daniel Velázquez-Díaz; Adrián Castillo-García; David Jiménez-Pavón; Alejandro Lucia; Carmen Fiuza-Luces Journal: Cancers (Basel) Date: 2021-12-24 Impact factor: 6.639