| Literature DB >> 31392694 |
Nicholas H Varvel1, Richard M Ransohoff2,3, Jonas J Neher4,5.
Abstract
During insults and disease blood-borne monocytes can invade brain and spinal cord, contributing to the neuroimmune response together with brain-resident microglia. The specific function of brain-infiltrating monocytes has been difficult to ascertain because of shared marker expression and morphology of these two immune cell types. Here we describe our method of repopulating the brain with circulating monocytes after microglia ablation to investigate the physiology of brain-invading monocytes, which engraft under these conditions.Entities:
Keywords: Flow cytometry; Microglia; Monocytes; Neuroinflammation; Transgenic mice
Mesh：
Year: 2019 PMID： 31392694 PMCID： PMC8991420 DOI： 10.1007/978-1-4939-9658-2_22
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745