| Literature DB >> 31392677 |
Darío Tejera1,2, Michael T Heneka3,4.
Abstract
Microglia are the brain's resident immune cells. Under physiological conditions, they participate in a myriad of processes mainly involved in housekeeping functions that promote tissue homeostasis. However, the triggering of an immune response is a common feature in neurodegenerative disorders. This shift in microglia cells toward a chronically activated phenotype contributing to neuronal dysfunction and cell death is of great interest nowadays. In this chapter, we review the implications of microglia activation in different neurodegenerative disorders.Entities:
Keywords: ALS; Aggregation; Alzheimer; FTD; Homeostasis; Microglia; Neurodegeneration; Parkinson
Mesh：
Year: 2019 PMID： 31392677 DOI： 10.1007/978-1-4939-9658-2_5
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745