OBJECTIVE: To assess the diagnostic performance of International Ovarian Tumor Analysis (IOTA) simple ultrasound rules to discriminate adnexal masses as benign or malignant. METHODS: A cross-sectional prospective study was conducted on women scheduled for elective surgery due to adnexal masses. Ultrasound examiner systematically assessed the tumors according to the IOTA simple rules to determine the risk of the tumor being malignant. If the simple rules yielded inconclusive result, pattern recognition was used to categorize the mass. Results were then compared with histologic findings after surgery. Diagnostic performance was assessed by calculating sensitivity and specificity. RESULTS: Two hundred and five women undergoing surgery were included. The rules were applicable in 183 (89.3%) of the tumors; and for these tumors, sensitivity was 92.8% (95% CI 77-99%) and specificity was 92.9% (95% CI 88-96.4%). Of the tumors, 144 were benign and 39 were malignant. The simple rules yielded inconclusive results in 22 masses which were analyzed by pattern recognition. CONCLUSION: IOTA simple rules provide excellent discrimination between benign and malignant adnexal masses.
OBJECTIVE: To assess the diagnostic performance of International Ovarian Tumor Analysis (IOTA) simple ultrasound rules to discriminate adnexal masses as benign or malignant. METHODS: A cross-sectional prospective study was conducted on women scheduled for elective surgery due to adnexal masses. Ultrasound examiner systematically assessed the tumors according to the IOTA simple rules to determine the risk of the tumor being malignant. If the simple rules yielded inconclusive result, pattern recognition was used to categorize the mass. Results were then compared with histologic findings after surgery. Diagnostic performance was assessed by calculating sensitivity and specificity. RESULTS: Two hundred and five women undergoing surgery were included. The rules were applicable in 183 (89.3%) of the tumors; and for these tumors, sensitivity was 92.8% (95% CI 77-99%) and specificity was 92.9% (95% CI 88-96.4%). Of the tumors, 144 were benign and 39 were malignant. The simple rules yielded inconclusive results in 22 masses which were analyzed by pattern recognition. CONCLUSION: IOTA simple rules provide excellent discrimination between benign and malignant adnexal masses.
Authors: D Timmerman; B Van Calster; A C Testa; S Guerriero; D Fischerova; A A Lissoni; C Van Holsbeke; R Fruscio; A Czekierdowski; D Jurkovic; L Savelli; I Vergote; T Bourne; S Van Huffel; L Valentin Journal: Ultrasound Obstet Gynecol Date: 2010-08 Impact factor: 7.299
Authors: Caroline Van Holsbeke; Ben Van Calster; Lil Valentin; Antonia C Testa; Enrico Ferrazzi; Ioannis Dimou; Chuan Lu; Philippe Moerman; Sabine Van Huffel; Ignace Vergote; Dirk Timmerman Journal: Clin Cancer Res Date: 2007-08-01 Impact factor: 12.531
Authors: Ben Van Calster; Dirk Timmerman; Tom Bourne; Antonia Carla Testa; Caroline Van Holsbeke; Ekaterini Domali; Davor Jurkovic; Patrick Neven; Sabine Van Huffel; Lil Valentin Journal: J Natl Cancer Inst Date: 2007-11-13 Impact factor: 13.506
Authors: Dirk Timmerman; Antonia C Testa; Tom Bourne; Enrico Ferrazzi; Lieveke Ameye; Maja L Konstantinovic; Ben Van Calster; William P Collins; Ignace Vergote; Sabine Van Huffel; Lil Valentin Journal: J Clin Oncol Date: 2005-12-01 Impact factor: 44.544
Authors: D Timmerman; A C Testa; T Bourne; L Ameye; D Jurkovic; C Van Holsbeke; D Paladini; B Van Calster; I Vergote; S Van Huffel; L Valentin Journal: Ultrasound Obstet Gynecol Date: 2008-06 Impact factor: 7.299
Authors: Dirk Timmerman; Lieveke Ameye; Daniela Fischerova; Elisabeth Epstein; Gian Benedetto Melis; Stefano Guerriero; Caroline Van Holsbeke; Luca Savelli; Robert Fruscio; Andrea Alberto Lissoni; Antonia Carla Testa; Joan Veldman; Ignace Vergote; Sabine Van Huffel; Tom Bourne; Lil Valentin Journal: BMJ Date: 2010-12-14