Literature DB >> 31391716

Alkaline Phosphatase Activity of Normal and Malignant Human Lymphocytes.

B Nageshwari1, Ramchander Merugu2.   

Abstract

Bone marrow aspirates form patients with multiple myeloma were obtained and lymphocytes were isolated using density gradient centrifugation. The APase activity of the samples ranged from 12 to 88 nmol/0.2 × 106 cells as compared to the very low activity present in normal human peripheral blood lymphocytes PBL. Neither the unstimulated nor the mitogen stimulated lymphocytes from peripheral blood of normal humans showed appreciable APase activity. The lymphocytes from bone marrow of multiple myeloma patients as well as myeloma cell lines-RPMI 8226 and U266 B1 express APase activity constitutively. The results of the present investigation are discussed in the light of existing literature.

Entities:  

Keywords:  Alkaline phosphatase; Human peripheral blood lymphocytes; U266B1 and RPMI 8226

Year:  2018        PMID： 31391716      PMCID： PMC6660519          DOI： 10.1007/s12291-018-0757-7

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  13 in total

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Authors:  M E De Broe; V O Van Hoof
Journal:  Clin Chem       Date:  1991-06       Impact factor: 8.327

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Journal:  Biochem Biophys Res Commun       Date:  1991-05-31       Impact factor: 3.575

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Journal:  J Immunol       Date:  1989-05-01       Impact factor: 5.422

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Journal:  J Immunol       Date:  1981-05       Impact factor: 5.422

6.  A novel coronavirus associated with severe acute respiratory syndrome.

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Journal:  N Engl J Med       Date:  2003-04-10       Impact factor: 91.245

7.  Neutrophil alkaline phosphatase: comparison of enzymes from normal subjects and patients with polycythemia vera and chronic myelogenous leukemia.

Authors:  D Rosenblum; S J Petzold
Journal:  Blood       Date:  1975-03       Impact factor: 22.113

8.  Competitive, uncompetitive, and mixed inhibitors of the alkaline phosphatase activity associated with the isolated brush border membrane of the tapeworm Hymenolepis diminuta.

Authors:  P W Pappas; D A Leiby
Journal:  J Cell Biochem       Date:  1989-06       Impact factor: 4.429

9.  Identification of the HeLa tumor-associated antigen, p75/150, as intestinal alkaline phosphatase and evidence for its transcriptional regulation.

Authors:  K M Latham; E J Stanbridge
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

10.  Comparative study of alkaline phosphatase activity in lymphocytes, mitogen-induced blasts, lymphoblastoid cell lines, acute myeloid leukemia, and chronic lymphatic leukemia cells.

Authors:  H Neumann; E Klein; R Hauck-Granoth; S Yachnin; H Ben-Bassat
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205
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