| Literature DB >> 31390217 |
Zheng-Jun Wang1,2, Shuai Zheng1, Eugénie Romero1, Jennifer K Matsui1, Gary A Molander1.
Abstract
A radical-mediated functionalization of allyl alcohol derived partners with a variety of alkyl 1,4-dihydropyridines via photoredox/nickel dual catalysis is described. This transformation transpires with high linear and E-selectivity, avoiding the requirement of harsh conditions (e.g., strong base, elevated temperature). Additionally, using aryl sulfinate salts as radical precursors, allyl sulfones can also be obtained. Kinetic isotope effect experiments implicated oxidative addition of the nickel catalyst to the allylic electrophile as the turnover-limiting step, supporting previous computational studies.Entities:
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Year: 2019 PMID： 31390217 PMCID： PMC7091330 DOI： 10.1021/acs.orglett.9b02473
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005