Literature DB >> 31389776

Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders.

Jason W Adams1,2,3, Fernanda R Cugola1,2, Alysson R Muotri1,2.   

Abstract

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. We review here how brain organoids have been used to study neurodevelopmental disease and consider their potential for both technological advancement and therapeutic development.

Entities:  

Keywords:  disease modeling; neurodevelopmental disease; organoids; stem cells

Mesh：

Year:  2019        PMID： 31389776      PMCID： PMC6863377          DOI： 10.1152/physiol.00005.2019

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  141 in total

1.  Genetic heterogeneity in human disease.

Authors:  Jon McClellan; Mary-Claire King
Journal:  Cell       Date:  2010-04-16       Impact factor: 41.582

2.  Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.

Authors:  Anca M Paşca; Steven A Sloan; Laura E Clarke; Yuan Tian; Christopher D Makinson; Nina Huber; Chul Hoon Kim; Jin-Young Park; Nancy A O'Rourke; Khoa D Nguyen; Stephen J Smith; John R Huguenard; Daniel H Geschwind; Ben A Barres; Sergiu P Paşca
Journal:  Nat Methods       Date:  2015-05-25       Impact factor: 28.547

3.  Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Authors:  Cleber A Trujillo; Richard Gao; Priscilla D Negraes; Jing Gu; Justin Buchanan; Sebastian Preissl; Allen Wang; Wei Wu; Gabriel G Haddad; Isaac A Chaim; Alain Domissy; Matthieu Vandenberghe; Anna Devor; Gene W Yeo; Bradley Voytek; Alysson R Muotri
Journal:  Cell Stem Cell       Date:  2019-08-29       Impact factor: 24.633

Review 4.  Severe congenital encephalopathy caused by MECP2 null mutations in males: central hypoxia and reduced neuronal dendritic structure.

Authors:  B Schüle; D D Armstrong; H Vogel; A Oviedo; U Francke
Journal:  Clin Genet       Date:  2008-05-08       Impact factor: 4.438

5.  mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism.

Authors:  S Hossein Fatemi; Teri J Reutiman; Timothy D Folsom; Robert J Rooney; Diven H Patel; Paul D Thuras
Journal:  J Autism Dev Disord       Date:  2010-06

6.  Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.

Authors:  Stuart M Chambers; Christopher A Fasano; Eirini P Papapetrou; Mark Tomishima; Michel Sadelain; Lorenz Studer
Journal:  Nat Biotechnol       Date:  2009-03-01       Impact factor: 54.908

7.  Generation and assembly of human brain region-specific three-dimensional cultures.

Authors:  Steven A Sloan; Jimena Andersen; Anca M Pașca; Fikri Birey; Sergiu P Pașca
Journal:  Nat Protoc       Date:  2018-09       Impact factor: 13.491

8.  Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.

Authors:  J Gray Camp; Farhath Badsha; Marta Florio; Sabina Kanton; Tobias Gerber; Michaela Wilsch-Bräuninger; Eric Lewitus; Alex Sykes; Wulf Hevers; Madeline Lancaster; Juergen A Knoblich; Robert Lachmann; Svante Pääbo; Wieland B Huttner; Barbara Treutlein
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-07       Impact factor: 11.205

9.  Brain Cell Type Specific Gene Expression and Co-expression Network Architectures.

Authors:  Andrew T McKenzie; Minghui Wang; Mads E Hauberg; John F Fullard; Alexey Kozlenkov; Alexandra Keenan; Yasmin L Hurd; Stella Dracheva; Patrizia Casaccia; Panos Roussos; Bin Zhang
Journal:  Sci Rep       Date:  2018-06-11       Impact factor: 4.379

10.  Human Brain Organoids on a Chip Reveal the Physics of Folding.

Authors:  Eyal Karzbrun; Aditya Kshirsagar; Sidney R Cohen; Jacob H Hanna; Orly Reiner
Journal:  Nat Phys       Date:  2018-02-19       Impact factor: 20.034
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  14 in total

Review 1.  Modeling Psychiatric Disorder Biology with Stem Cells.

Authors:  Debamitra Das; Kyra Feuer; Marah Wahbeh; Dimitrios Avramopoulos
Journal:  Curr Psychiatry Rep       Date:  2020-04-21       Impact factor: 5.285

Review 2.  Cerebral organoids as an in vitro model to study autism spectrum disorders.

Authors:  Alexa Rabeling; Mubeen Goolam
Journal:  Gene Ther       Date:  2022-07-05       Impact factor: 5.250

3.  Building the brain from scratch: Engineering region-specific brain organoids from human stem cells to study neural development and disease.

Authors:  Fadi Jacob; Jordan G Schnoll; Hongjun Song; Guo-Li Ming
Journal:  Curr Top Dev Biol       Date:  2021-02-18       Impact factor: 4.897

4.  Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids.

Authors:  Cleber A Trujillo; Jason W Adams; Priscilla D Negraes; Cassiano Carromeu; Leon Tejwani; Allan Acab; Ben Tsuda; Charles A Thomas; Neha Sodhi; Katherine M Fichter; Sarah Romero; Fabian Zanella; Terrence J Sejnowski; Henning Ulrich; Alysson R Muotri
Journal:  EMBO Mol Med       Date:  2020-12-08       Impact factor: 14.260

Review 5.  Region Specific Brain Organoids to Study Neurodevelopmental Disorders.

Authors:  Praveen Joseph Susaimanickam; Ferdi Ridvan Kiral; In-Hyun Park
Journal:  Int J Stem Cells       Date:  2022-02-28       Impact factor: 2.500

Review 6.  Modeling neurological disorders using brain organoids.

Authors:  Daniel Y Zhang; Hongjun Song; Guo-Li Ming
Journal:  Semin Cell Dev Biol       Date:  2020-06-17       Impact factor: 7.727

Review 7.  From Brain Organoids to Networking Assembloids: Implications for Neuroendocrinology and Stress Medicine.

Authors:  Evanthia A Makrygianni; George P Chrousos
Journal:  Front Physiol       Date:  2021-06-10       Impact factor: 4.566

Review 8.  Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms.

Authors:  Agustín Cota-Coronado; Jennifer C Durnall; Néstor Fabián Díaz; Lachlan H Thompson; N Emmanuel Díaz-Martínez
Journal:  Molecules       Date:  2020-03-04       Impact factor: 4.411

Review 9.  Modeling neuronal consequences of autism-associated gene regulatory variants with human induced pluripotent stem cells.

Authors:  P Joel Ross; Rebecca S F Mok; Brandon S Smith; Deivid C Rodrigues; Marat Mufteev; Stephen W Scherer; James Ellis
Journal:  Mol Autism       Date:  2020-05-12       Impact factor: 7.509

Review 10.  The Application of Brain Organoids: From Neuronal Development to Neurological Diseases.

Authors:  Yikai Shou; Feng Liang; Shunliang Xu; Xuekun Li
Journal:  Front Cell Dev Biol       Date:  2020-10-22
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