Zhuang Zuo1, Shaoying Li1, Jie Xu1, M James You1, Joseph D Khoury1, C Cameron Yin2. 1. Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 2. Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. cyin@mdanderson.org.
Abstract
PURPOSE OF REVIEW: To review the impact of next-generation sequencing (NGS) on laboratory approach of myeloproliferative neoplasms (MPNs). RECENT FINDINGS: Next-generation sequencing has provided valuable information on the mutational landscape of MPNs and has been used for various applications, including diagnosis, risk stratification, monitoring of residual disease or disease progression, and target therapy. Most commonly, targeted sequencing of a panel of genes that have been shown to be recurrently mutated in myeloid neoplasms is used. Although numerous studies have shown the benefit of using NGS in the routine clinical care of MPN patients, the complexity of NGS data and how these data may contribute to the clinical outcome have limited the development of a standard clinical guideline. We review recent literature and discuss how to interpret and use NGS data in the clinical care of MPN patients.
PURPOSE OF REVIEW: To review the impact of next-generation sequencing (NGS) on laboratory approach of myeloproliferative neoplasms (MPNs). RECENT FINDINGS: Next-generation sequencing has provided valuable information on the mutational landscape of MPNs and has been used for various applications, including diagnosis, risk stratification, monitoring of residual disease or disease progression, and target therapy. Most commonly, targeted sequencing of a panel of genes that have been shown to be recurrently mutated in myeloid neoplasms is used. Although numerous studies have shown the benefit of using NGS in the routine clinical care of MPN patients, the complexity of NGS data and how these data may contribute to the clinical outcome have limited the development of a standard clinical guideline. We review recent literature and discuss how to interpret and use NGS data in the clinical care of MPN patients.
Authors: Paola Guglielmelli; Flavia Biamonte; Joannah Score; Claire Hidalgo-Curtis; Francisco Cervantes; Margherita Maffioli; Tiziana Fanelli; Thomas Ernst; Nils Winkelman; Amy V Jones; Katerina Zoi; Andreas Reiter; Andrew Duncombe; Laura Villani; Alberto Bosi; Giovanni Barosi; Nicholas C P Cross; Alessandro M Vannucchi Journal: Blood Date: 2011-09-14 Impact factor: 22.113
Authors: Chloé James; Valérie Ugo; Jean-Pierre Le Couédic; Judith Staerk; François Delhommeau; Catherine Lacout; Loïc Garçon; Hana Raslova; Roland Berger; Annelise Bennaceur-Griscelli; Jean Luc Villeval; Stefan N Constantinescu; Nicole Casadevall; William Vainchenker Journal: Nature Date: 2005-04-28 Impact factor: 49.962
Authors: Terra L Lasho; Mythri Mudireddy; Christy M Finke; Curtis A Hanson; Rhett P Ketterling; Natasha Szuber; Kebede H Begna; Mrinal M Patnaik; Naseema Gangat; Animesh Pardanani; Ayalew Tefferi Journal: Blood Adv Date: 2018-02-27
Authors: E Joanna Baxter; Linda M Scott; Peter J Campbell; Clare East; Nasios Fourouclas; Soheila Swanton; George S Vassiliou; Anthony J Bench; Elaine M Boyd; Natasha Curtin; Mike A Scott; Wendy N Erber; Anthony R Green Journal: Lancet Date: 2005 Mar 19-25 Impact factor: 79.321
Authors: A M Vannucchi; T L Lasho; P Guglielmelli; F Biamonte; A Pardanani; A Pereira; C Finke; J Score; N Gangat; C Mannarelli; R P Ketterling; G Rotunno; R A Knudson; M C Susini; R R Laborde; A Spolverini; A Pancrazzi; L Pieri; R Manfredini; E Tagliafico; R Zini; A Jones; K Zoi; A Reiter; A Duncombe; D Pietra; E Rumi; F Cervantes; G Barosi; M Cazzola; N C P Cross; A Tefferi Journal: Leukemia Date: 2013-04-26 Impact factor: 11.528
Authors: Francis H Grand; Claire E Hidalgo-Curtis; Thomas Ernst; Katerina Zoi; Christine Zoi; Carolann McGuire; Sebastian Kreil; Amy Jones; Joannah Score; Georgia Metzgeroth; David Oscier; Andrew Hall; Christian Brandts; Hubert Serve; Andreas Reiter; Andrew J Chase; Nicholas C P Cross Journal: Blood Date: 2009-04-22 Impact factor: 22.113
Authors: Julia E Maxson; Jason Gotlib; Daniel A Pollyea; Angela G Fleischman; Anupriya Agarwal; Christopher A Eide; Daniel Bottomly; Beth Wilmot; Shannon K McWeeney; Cristina E Tognon; J Blake Pond; Robert H Collins; Basem Goueli; Stephen T Oh; Michael W Deininger; Bill H Chang; Marc M Loriaux; Brian J Druker; Jeffrey W Tyner Journal: N Engl J Med Date: 2013-05-09 Impact factor: 91.245
Authors: Yana Pikman; Benjamin H Lee; Thomas Mercher; Elizabeth McDowell; Benjamin L Ebert; Maricel Gozo; Adam Cuker; Gerlinde Wernig; Sandra Moore; Ilene Galinsky; Daniel J DeAngelo; Jennifer J Clark; Stephanie J Lee; Todd R Golub; Martha Wadleigh; D Gary Gilliland; Ross L Levine Journal: PLoS Med Date: 2006-07 Impact factor: 11.069
Authors: Samah Alimam; William Villiers; Richard Dillon; Michael Simpson; Manohursingh Runglall; Alexander Smith; Prodromos Chatzikyriakou; Paul Lavender; Anju Kanda; Ken Mills; Beatriz Bellosillo Paricio; James Kaufman-Cook; Sophie Ord; Shahram Kordasti; Deepti Radia; Claire Woodley; Yvonne Francis; Ghulam Mufti; Donal P McLornan; Claire N Harrison Journal: Blood Adv Date: 2021-02-23