M Çetin1, T Erdoğan1, T Kırış2, S Özer1, A S Yılmaz1, H Durak1, A Ç Aykan3, Ö Şatıroğlu1. 1. Faculty of Medicine, Department of Cardiology, Recep Tayyip Erdogan University, Rize, Turkey. 2. Ataturk Training and Research Hospital, Department of Cardiology, Izmir Katip Celebi University, Izmir, Turkey. drtkiris@hotmail.com. 3. Department of Cardiology, University of Sutcu Imam, Kahramanmaras, Turkey.
Abstract
BACKGROUND: We aimed to investigate the predictive value of the fibrinogen-to-albumin ratio (FAR) regarding the development of major cardiovascular events (MACE) in patients treated with percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). METHODS: This was a prospective, observational cohort study that included 261 consecutive patients who were treated with PCI. The patients were grouped according to the occurrence of MACE during the follow-up period. RESULTS: During follow-up, MACE occurred in 68 (26%) patients. The FAR was independently predictive of MACE (HR: 1.017, 95% CI: 1.010-1.024, p < 0.001). In addition, left ventricular ejection fraction (LVEF) and a diagnosis of ST-segment elevation myocardial infarction (STEMI) were independent predictors of MACE. The area under the curve (AUC) of the multivariable model, including LVEF and diagnosis of STEMI, was 0.707 (95% CI: 0.631-0.782, p < 0.001). When the FAR was added to the multivariable model, the AUC was 0.770 (95% CI: 0.702-0.838, z = 2.820, difference p = 0.0048). CONCLUSION: The FAR could be used for the prediction of MACE in patients with ACS who have undergone PCI.
BACKGROUND: We aimed to investigate the predictive value of the fibrinogen-to-albumin ratio (FAR) regarding the development of major cardiovascular events (MACE) in patients treated with percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). METHODS: This was a prospective, observational cohort study that included 261 consecutive patients who were treated with PCI. The patients were grouped according to the occurrence of MACE during the follow-up period. RESULTS: During follow-up, MACE occurred in 68 (26%) patients. The FAR was independently predictive of MACE (HR: 1.017, 95% CI: 1.010-1.024, p < 0.001). In addition, left ventricular ejection fraction (LVEF) and a diagnosis of ST-segment elevation myocardial infarction (STEMI) were independent predictors of MACE. The area under the curve (AUC) of the multivariable model, including LVEF and diagnosis of STEMI, was 0.707 (95% CI: 0.631-0.782, p < 0.001). When the FAR was added to the multivariable model, the AUC was 0.770 (95% CI: 0.702-0.838, z = 2.820, difference p = 0.0048). CONCLUSION: The FAR could be used for the prediction of MACE in patients with ACS who have undergone PCI.
Entities:
Keywords:
Acute coronary syndromes; Fibrinogen-to-albumin ratio; Major adverse cardiovascular events
Authors: Juan R Ulloque-Badaracco; Esteban A Alarcon-Braga; Enrique A Hernandez-Bustamante; Ali Al-Kassab-Córdova; Melany D Mosquera-Rojas; Ricardo R Ulloque-Badaracco; Miguel A Huayta-Cortez; Sherelym H Maita-Arauco; Percy Herrera-Añazco; Vicente A Benites-Zapata Journal: Trop Med Infect Dis Date: 2022-07-27