Monika E Danielewska1, Alina Messner2, René M Werkmeister2, Michał M Placek1, Valentin Aranha Dos Santos2, Marek Rękas3, Leopold Schmetterer2,4,5,6,7. 1. Wrocław University of Science and Technology, Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław, Poland. 2. Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria. 3. Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland. 4. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. 5. Academic Clinical Program, Duke-NUS Medical School, Singapore. 6. Department of Ophthalmology, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. 7. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Abstract
PURPOSE: To estimate the relationship between the characteristics of the corneal pulse (CP) signal and those of the fundus pulse (FP) signal measured with a combined noncontact ultrasonic and laser interferometry technique in healthy subjects. METHODS: Twenty-two healthy subjects participated in experiments that included measurements of intraocular pressure, ocular pulse amplitude, ocular biometry, blood pressure, and heart rate. Additionally, simultaneous recordings of CP and FP signals were acquired with a noncontact ultrasonic device combined with laser interferometry. Subsequently, ocular perfusion pressure (OPP) and the time and spectral parameters of CP and FP signals were computed. A system model was proposed to relate the FP signal to the CP signal. RESULTS: The system model revealed that the eye globe transfers information between signals of the posterior and anterior eye, relatively amplifying higher spectral harmonics. The amplitude of the second CP harmonic is predicted by FPRMS and OPP (R 2 = 0.468, P = 0.002). Partial correlation analysis showed that the CP signal parameters are statistically significantly correlated with those of the FP signal and OPP, after correcting for age and sex. CONCLUSIONS: The eye globe can be viewed as a high pass filter, in which the CP characteristic changes in relation to the fundus pulsation. The FP signal and OPP have an impact on the variations of the CP signal morphology. TRANSLATIONAL RELEVANCE: Investigation of differences between the characteristics of the anterior and posterior tissue movements is a promising method for evaluating the role of circulatory and biomechanical components in the pathophysiology of ocular diseases.
PURPOSE: To estimate the relationship between the characteristics of the corneal pulse (CP) signal and those of the fundus pulse (FP) signal measured with a combined noncontact ultrasonic and laser interferometry technique in healthy subjects. METHODS: Twenty-two healthy subjects participated in experiments that included measurements of intraocular pressure, ocular pulse amplitude, ocular biometry, blood pressure, and heart rate. Additionally, simultaneous recordings of CP and FP signals were acquired with a noncontact ultrasonic device combined with laser interferometry. Subsequently, ocular perfusion pressure (OPP) and the time and spectral parameters of CP and FP signals were computed. A system model was proposed to relate the FP signal to the CP signal. RESULTS: The system model revealed that the eye globe transfers information between signals of the posterior and anterior eye, relatively amplifying higher spectral harmonics. The amplitude of the second CP harmonic is predicted by FPRMS and OPP (R 2 = 0.468, P = 0.002). Partial correlation analysis showed that the CP signal parameters are statistically significantly correlated with those of the FP signal and OPP, after correcting for age and sex. CONCLUSIONS: The eye globe can be viewed as a high pass filter, in which the CP characteristic changes in relation to the fundus pulsation. The FP signal and OPP have an impact on the variations of the CP signal morphology. TRANSLATIONAL RELEVANCE: Investigation of differences between the characteristics of the anterior and posterior tissue movements is a promising method for evaluating the role of circulatory and biomechanical components in the pathophysiology of ocular diseases.
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