Literature DB >> 31387763

The Molecular Function of σ Receptors: Past, Present, and Future.

Hayden R Schmidt1, Andrew C Kruse2.   

Abstract

The σ1 and σ2 receptors are enigmatic proteins that have attracted attention for decades due to the chemical diversity and therapeutic potential of their ligands. However, despite ongoing clinical trials with σ receptor ligands for multiple conditions, relatively little is known regarding the molecular function of these receptors. In this review, we revisit past research on σ receptors and discuss the interpretation of these data in light of recent developments. We provide a synthesis of emerging structural and genetic data on the σ1 receptor and discuss the recent cloning of the σ2 receptor. Finally, we discuss the major questions that remain in the study of σ receptors.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  molecular pharmacology; structural pharmacology; σ(1) receptor; σ(2) receptor/TMEM97

Mesh：

Substances：

Year:  2019        PMID： 31387763      PMCID： PMC6748033          DOI： 10.1016/j.tips.2019.07.006

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  118 in total

1.  The sigma receptor as a ligand-regulated auxiliary potassium channel subunit.

Authors:  Ebru Aydar; Christopher P Palmer; Vitaly A Klyachko; Meyer B Jackson
Journal:  Neuron       Date:  2002-04-25       Impact factor: 17.173

Review 2.  Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach.

Authors:  R A Glennon
Journal:  Mini Rev Med Chem       Date:  2005-10       Impact factor: 3.862

3.  Is the sigma2 receptor a histone binding protein?

Authors:  Nicola Antonio Colabufo; Francesco Berardi; Carmen Abate; Marialessandra Contino; Mauro Niso; Roberto Perrone
Journal:  J Med Chem       Date:  2006-07-13       Impact factor: 7.446

4.  Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.

Authors:  Hongling Zhang; Javier Cuevas
Journal:  J Neurophysiol       Date:  2002-06       Impact factor: 2.714

5.  Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice.

Authors:  V L Phan; T P Su; A Privat; T Maurice
Journal:  Eur J Neurosci       Date:  1999-07       Impact factor: 3.386

6.  Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.

Authors:  Christopher Katnik; Waldo R Guerrero; Keith R Pennypacker; Yelenis Herrera; Javier Cuevas
Journal:  J Pharmacol Exp Ther       Date:  2006-09-20       Impact factor: 4.030

7.  Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.

Authors:  T Hayashi; T Maurice; T P Su
Journal:  J Pharmacol Exp Ther       Date:  2000-06       Impact factor: 4.030

8.  Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl- channels.

Authors:  Adrien Renaudo; Sébastien L'Hoste; Hélène Guizouarn; Franck Borgèse; Olivier Soriani
Journal:  J Biol Chem       Date:  2006-11-22       Impact factor: 5.157

9.  Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export.

Authors:  Teruo Hayashi; Tsung-Ping Su
Journal:  J Pharmacol Exp Ther       Date:  2003-05-02       Impact factor: 4.030

10.  Regulating ankyrin dynamics: Roles of sigma-1 receptors.

Authors:  T Hayashi; T P Su
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-09       Impact factor: 11.205
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  39 in total

1.  Wildtype sigma-1 receptor and the receptor agonist improve ALS-associated mutation-induced insolubility and toxicity.

Authors:  Yasuharu Shinoda; Yudai Haga; Koichiro Akagawa; Kohji Fukunaga
Journal:  J Biol Chem       Date:  2020-10-14       Impact factor: 5.157

2.  Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.

Authors:  Emanuele Amata; Maria Dichiara; Davide Gentile; Agostino Marrazzo; Rita Turnaturi; Emanuela Arena; Alfonsina La Mantia; Barbara Rita Tomasello; Rosaria Acquaviva; Claudia Di Giacomo; Antonio Rescifina; Orazio Prezzavento
Journal:  ACS Med Chem Lett       Date:  2020-04-09       Impact factor: 4.345

3.  Comprehensive Preclinical Assessment of Sensory, Functional, Motivational-Affective, and Neurochemical Outcomes in Neuropathic Pain: The Case of the Sigma-1 Receptor.

Authors:  Beatriz de la Puente; Daniel Zamanillo; Luz Romero; Alicia Carceller; José Miguel Vela; Manuel Merlos; Enrique Portillo-Salido
Journal:  ACS Pharmacol Transl Sci       Date:  2022-03-17

4.  Neuroprotective Effects of σ2R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington's Disease.

Authors:  Jing Jin; Nicolas Arbez; James J Sahn; Yan Lu; Kathryn T Linkens; Timothy R Hodges; Anthony Tang; Robyn Wiseman; Stephen F Martin; Christopher A Ross
Journal:  ACS Chem Neurosci       Date:  2022-09-15       Impact factor: 5.780

5.  Wildtype σ1 receptor and the receptor agonist improve ALS-associated mutation-induced insolubility and toxicity.

Authors:  Yasuharu Shinoda; Yudai Haga; Koichiro Akagawa; Kohji Fukunaga
Journal:  J Biol Chem       Date:  2020-12-18       Impact factor: 5.157

6.  Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain.

Authors:  Shao-Ming Wang; Nino Goguadze; Yuriko Kimura; Yuko Yasui; Bin Pan; Tzu-Yun Wang; Yoki Nakamura; Yu-Ting Lin; Quinn H Hogan; Katherine L Wilson; Tsung-Ping Su; Hsiang-En Wu
Journal:  Mol Neurobiol       Date:  2021-01-18       Impact factor: 5.590

7.  The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains.

Authors:  Vladimir Zhemkov; Jonathon A Ditlev; Wan-Ru Lee; Mikaela Wilson; Jen Liou; Michael K Rosen; Ilya Bezprozvanny
Journal:  Elife       Date:  2021-05-11       Impact factor: 8.140

Review 8.  Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives.

Authors:  Francesca Serena Abatematteo; Mauro Niso; Marialessandra Contino; Marcello Leopoldo; Carmen Abate
Journal:  Int J Mol Sci       Date:  2021-06-14       Impact factor: 5.923

9.  The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice.

Authors:  Sema G Quadir; Sean M Tanino; Christian D Rohl; James J Sahn; Emily J Yao; Luíza Dos Reis Cruz; Pietro Cottone; Stephen F Martin; Valentina Sabino
Journal:  Neuropharmacology       Date:  2020-11-20       Impact factor: 5.250

10.  Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective.

Authors:  Antonino N Fallica; Valeria Pittalà; Maria N Modica; Loredana Salerno; Giuseppe Romeo; Agostino Marrazzo; Mohamed A Helal; Sebastiano Intagliata
Journal:  J Med Chem       Date:  2021-06-02       Impact factor: 7.446
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