| Literature DB >> 31387188 |
Yuhang Xiao1, Min Su2, Wei Ou3, Hui Wang4, Bo Tian5, Junliang Ma5, Jinming Tang5, Jie Wu5, Zhining Wu5, Wenxiang Wang6, Yong Zhou7.
Abstract
Esophageal cancer (EC) is a serious digestive malignancy and is a leading cause of cancer-related mortality. Apart from genetic mutations, many epigenetic alterations including DNA methylation and histone modifications associated with chromatin remodeling have been identified in the regulation of gene expression in EC. Recently, noncoding RNAs, and mainly lncRNAs and miRNAs, have been revealed to be involved in the epigenetic regulation of EC. In this review, we focus on describing new insights on epigenetic processes associated with noncoding RNAs, which have been characterized to be responsible for the development and progression of EC.Entities:
Keywords: DNA methylation; Epigenetic alteration; Esophageal cancer; Histone modification; Noncoding RNA; lncRNA; miRNA
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Year: 2019 PMID： 31387188 DOI： 10.1016/j.biopha.2019.109192
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529