| Literature DB >> 31387004 |
Milan Jakubek1, Zdeněk Kejík2, Robert Kaplánek3, Róbert Hromádka4, Viera Šandriková5, David Sýkora6, Veronika Antonyová2, Marian Urban7, Petr Dytrych8, Ivan Mikula9, Pavel Martásek10, Vladimír Král11.
Abstract
Gastric cancer is a common oncological disease. Although enormous efforts have been expended, possible therapeutic modalities are still limited. For this reason, new therapeutic approaches and agents are highly requested and intensively developed. One strategy is the application of natural agents, such as curcumin, with proven anticancer effects and low toxicity for patients. Therefore, this review discusses the potential application of curcumin in the therapy of gastric cancer and its potential incorporation in therapeutic regimens. Because one of the largest impediments for widespread curcumin application is its limited bioavailability (caused mainly by its very low water solubility), studied strategies (drug delivery systems and curcumin derivatization) aimed to solve this obstacle are discussed in more detail.Entities:
Keywords: Combination therapy; Curcumin; Curcumin derivatives; Drug delivery system; Gastric cancer
Year: 2019 PMID： 31387004 DOI： 10.1016/j.biopha.2019.109278
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529